INT180795

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.10
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neuron 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 96 100.00 Very High Very High Very High
Hyperalgesia 31 95.60 Very High Very High Very High
Nerve growth factor 102 89.96 High High
qutenza 52 62.80 Quite High
nociceptor 28 53.84 Quite High
Pain 29 50.00 Quite Low
Neuropeptide 11 50.00 Quite Low
Trigeminal ganglion neurons 1 50.00 Quite Low
trigeminal ganglion 59 13.40 Low Low
agonist 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 35 95.60 Very High Very High Very High
Ganglion Cysts 73 50.00 Quite Low
Pain 29 50.00 Quite Low
Starvation 4 31.84 Quite Low
Nociception 52 20.16 Low Low
Injury 27 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore EGF stimulation should result in a higher number of cells showing an increasing pErk1/2 signal than in response to NGF or GDNF stimulation.
Positive_regulation (response) of Positive_regulation (stimulation) of GDNF
1) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0
Next we tested for detection of pErk1/2 intensities in response to known activators of Erk1/2, NGF and GDNF.
Positive_regulation (response) of Positive_regulation (activators) of GDNF
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.10 Pain Relevance 0.10
Interestingly, the GDNF augmentation of CGRP release appeared to be due primarily to the large increases in neuron survival, because only the 10 ng/ml GDNF condition was significantly greater than control (p < 0.001), but still substantial lower compared with the untransformed lysis figures (Fig. 6D).
Positive_regulation (due) of Positive_regulation (augmentation) of GDNF in neuron associated with calcitonin gene-related peptide
3) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.98

General Comments

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