INT180814

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) signal transduction (Ret)
extracellular region (Gdnf) kinase activity (Ret)
Anatomy Link Frequency
neurons 1
Ret (Mus musculus)
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 24 98.36 Very High Very High Very High
trigeminal ganglion 118 91.48 High High
Nerve growth factor 200 82.60 Quite High
qutenza 104 72.96 Quite High
Calcitonin gene-related peptide 192 67.44 Quite High
Neuropeptide 22 53.84 Quite High
Trigeminal ganglion neurons 2 50.00 Quite Low
Migraine 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 146 98.36 Very High Very High Very High
Nociception 16 81.84 Quite High
Disease 4 75.68 Quite High
Apoptosis 4 71.84 Quite High
Injury 46 5.00 Very Low Very Low Very Low
Hyperalgesia 14 5.00 Very Low Very Low Very Low
Headache 12 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, it has been suggested that GFR alpha-1 and GFR alpha-2-containing neurons in the adult rat make up two distinct populations in the DRG within the IB4-binding class [8]; hence, the effects observed here may be due to GDNF acting through its high affinity GFR alpha-1 site at the 1 ng/ml concentration and through either or both GFR alpha-1 and GFR alpha-2 / c-ret, for which it has a lower affinity, at the 100 ng/ml concentration.
c-ret Binding (affinity) of GDNF in neurons associated with dorsal root ganglion
1) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.78 Pain Relevance 0.46
GDNF binds most readily to GFR alpha-1, but also binds to GFR alpha-2 / c-ret heterodimers [50].
c-ret Binding (binds) of GDNF
2) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.52 Pain Relevance 0.71

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox