INT18084

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.60
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde11a) signal transduction (Pde11a) cytoplasm (Pde11a)
Anatomy Link Frequency
macrophages 2
fat 1
neurons 1
Pde11a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 28 99.98 Very High Very High Very High
adenocard 2 96.24 Very High Very High Very High
Action potential 3 94.84 High High
addiction 1 94.72 High High
Locus ceruleus 5 93.88 High High
sodium channel 1 92.24 High High
Calcium channel 2 80.64 Quite High
antagonist 4 79.68 Quite High
tetrodotoxin 1 60.24 Quite High
Angina 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 6 99.24 Very High Very High Very High
Increased Venous Pressure Under Development 9 85.36 High High
Heart Rate Under Development 2 83.84 Quite High
Pressure Volume 2 Under Development 2 71.04 Quite High
Myocardial Infarction 2 68.96 Quite High
Diabetes Mellitus 16 60.64 Quite High
Hepatic Insufficiency 2 58.24 Quite High
Erectile Dysfunction 69 50.00 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Hypertension 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Papaverine was found to possess marginal membrane channel-blocking activity and to be much more potent than diproteverine as a cAMP-phosphodiesterase inhibitor.
Negative_regulation (inhibitor) of cAMP-phosphodiesterase
1) Confidence 0.41 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2055233 Disease Relevance 0.21 Pain Relevance 0.29
The firing rate of locus coeruleus (LC) neurons in rat brain slices was increased reversibly by agents that either elevate intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) or mimic its actions (e.g., forskolin, and activator of adenylate cyclase, 8-Br-cAMP, a membrane permeable analog of cAMP, and Ro20-1724, a preferential inhibitor of cAMP-phosphodiesterase).
Negative_regulation (inhibitor) of cAMP-phosphodiesterase in neurons associated with adenocard and locus ceruleus
2) Confidence 0.33 Published 1987 Journal Synapse Section Abstract Doc Link 2463688 Disease Relevance 0 Pain Relevance 0.36
In vitro both fluphenazine and capsaicin inhibited Ca2(+)-Mg2+ ATPase and cAMP-phosphodiesterase from macrophages and this inhibition was reversed by exogenous addition of calmodulin.
Negative_regulation (reversed) of cAMP-phosphodiesterase in macrophages associated with qutenza
3) Confidence 0.15 Published 1990 Journal Cell. Signal. Section Abstract Doc Link 1964391 Disease Relevance 0 Pain Relevance 0.72
In vitro both fluphenazine and capsaicin inhibited Ca2(+)-Mg2+ ATPase and cAMP-phosphodiesterase from macrophages and this inhibition was reversed by exogenous addition of calmodulin.
Negative_regulation (inhibited) of cAMP-phosphodiesterase in macrophages associated with qutenza
4) Confidence 0.15 Published 1990 Journal Cell. Signal. Section Abstract Doc Link 1964391 Disease Relevance 0 Pain Relevance 0.71
Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet.
Negative_regulation (inhibit) of cAMP phosphodiesterase in fat associated with qutenza and obesity
5) Confidence 0.11 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3118870 Disease Relevance 0.10 Pain Relevance 0.41
With respect to PDE5, a 780-fold greater concentration of tadalafil is needed to inhibit PDE6, and a 14-fold greater concentration to inhibit PDE11, an enzyme with unknown physiological function.
Negative_regulation (inhibit) of PDE11
6) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.29 Pain Relevance 0

General Comments

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