INT18088

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 9.12
Pain Relevance 10.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
brain 4
striatum 1
spleen 1
dorsal horn 1
BZR 1
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 119 100.00 Very High Very High Very High
gABA 33 100.00 Very High Very High Very High
halothane 20 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
alcohol 209 99.92 Very High Very High Very High
Endogenous opioid 6 99.92 Very High Very High Very High
Cholecystokinin 84 99.90 Very High Very High Very High
dorsal root ganglion 12 99.60 Very High Very High Very High
Sciatic nerve 8 99.20 Very High Very High Very High
anesthesia 26 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 99.60 Very High Very High Very High
Anxiety Disorder 214 99.40 Very High Very High Very High
Injury 48 99.20 Very High Very High Very High
Sleep Disorders 50 98.26 Very High Very High Very High
Urological Neuroanatomy 52 97.64 Very High Very High Very High
Stress 213 97.60 Very High Very High Very High
Suicidal Behaviour 12 97.32 Very High Very High Very High
Herpes Simplex Encephalitis 246 93.32 High High
Toxicity 6 92.64 High High
Poisoning 3 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of an increase in the MAC of halothane in the presence of flumazenil suggests that halothane does not interact with the benzodiazepine receptor, directly or indirectly, to produce its anesthetic action.
benzodiazepine receptor Neg (not) Binding (interact) of associated with halothane
1) Confidence 0.48 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2539028 Disease Relevance 0 Pain Relevance 0.67
This raises the possibility that the presence of a social companion precludes the release of an endogenous anxiogen that binds to the benzodiazepine receptor.
benzodiazepine receptor Binding (binds) of
2) Confidence 0.48 Published 1990 Journal Dev Psychobiol Section Abstract Doc Link 1964442 Disease Relevance 0 Pain Relevance 0.48
In contrast to [11C]-(R)-PK11195, [11C]-DPA-713 is even able to show specific binding to the low basal expression levels of TSPO in control rats.
TSPO Binding (binding) of
3) Confidence 0.46 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.15 Pain Relevance 0
This higher uptake was shown to be selective TSPO binding.
TSPO Binding (binding) of
4) Confidence 0.46 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.24 Pain Relevance 0.26
Pyrazolopyrimidines display high affinity for the TSPO and two compounds from this class have already been radiolabeled for use in PET.
TSPO Binding (affinity) of associated with positron emission tomography
5) Confidence 0.46 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.45 Pain Relevance 0.38
However, FG 7142 is less potent than RO 15-4513 and has less affinity for the benzodiazepine receptor (BZR).
benzodiazepine receptor Binding (affinity) of in BZR
6) Confidence 0.42 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2111915 Disease Relevance 0 Pain Relevance 0.43
The effects of a benzodiazepine receptor agonist and an antagonist on the MAC of halothane required to achieve anesthesia were evaluated to explore the possible functional interaction between halothane and the benzodiazepine receptor.
benzodiazepine receptor Binding (interaction) of associated with anesthesia, antagonist, agonist and halothane
7) Confidence 0.37 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2539028 Disease Relevance 0 Pain Relevance 0.70
In naïve animals, PBR mRNA, protein expression and ligand binding are undetectable in the DRG.
PBR mRNA Binding (binding) of in DRG associated with dorsal root ganglion
8) Confidence 0.36 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.79 Pain Relevance 0.40
The pyrazolopyrimidines DPA-713 and DPA-714 have higher affinity for the TSPO in vitro (Ki?
TSPO Binding (affinity) of
9) Confidence 0.36 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.41 Pain Relevance 0.32
It was concluded that [11C]-DPA-713 is a specific ligand for the TSPO and that it may be useful for studying changes in the density of TSPO binding sites.
TSPO Binding (ligand) of
10) Confidence 0.36 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.31 Pain Relevance 0.27
The apparent discrepancy between the results of our study and those of the previous studies in the striatum lesion model might be due to differences in the affinity state of the receptor between both animal models. [18F]-DPA-714 is an agonist of the TSPO and an agonist usually binds only to the high affinity state of the receptor.
TSPO Binding (binds) of in striatum associated with agonist
11) Confidence 0.34 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.22 Pain Relevance 0.10
PBR ligand binding also appears after injury in the superficial dorsal horn of the spinal cord.
PBR Binding (binding) of in dorsal horn associated with injury, dorsal horn and spinal cord
12) Confidence 0.31 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.88 Pain Relevance 0.48
SSR180575 shows high affinity (IC(50), 2.5-3.5 nM) and selectivity for the rat and human PBR and potently inhibits the in vivo binding of [(3)H]alpidem to PBR in the rat brain and spleen after oral or i.p. administration (ID(50), 0.1-0.3 mg/kg).
PBR Binding (binding) of in brain
13) Confidence 0.31 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12023539 Disease Relevance 0.05 Pain Relevance 0.05
These include mediation via the GABA-benzodiazepine-ionophore complex, endogenous opioids, the hypothalamo-pituitary-adrenocortical axis and the noradrenergic system.
GABA-benzodiazepine-ionophore Binding (complex) of in pituitary associated with gaba and endogenous opioid
14) Confidence 0.31 Published 1990 Journal Alcohol Alcohol. Section Abstract Doc Link 1973897 Disease Relevance 0.61 Pain Relevance 0.37
Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze.
benzodiazepine receptor Binding (Interactions) of associated with gaba, narcan and agonist
15) Confidence 0.27 Published 2001 Journal J. Psychopharmacol. (Oxford) Section Title Doc Link 11448091 Disease Relevance 0.38 Pain Relevance 0.64
Both constituents interact with a mitochondrial protein, the adenine nucleotide translocator, responsible for the ATP/ADP antiport and involved in mitochondrial membrane permeabilization.
translocator Binding (interact) of
16) Confidence 0.25 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15707749 Disease Relevance 1.09 Pain Relevance 0.17
These results indicate that the ability of alcohol to potentiate benzodiazepine-induced sedation is not simply an additive effect but may be related to the facilitation by alcohol of benzodiazepine receptor binding.
benzodiazepine receptor Binding (binding) of associated with sleep disorders and alcohol
17) Confidence 0.20 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 2857540 Disease Relevance 0.35 Pain Relevance 0.78
In contrast, DAA1097 and DAA1106 did not inhibit [3H]-flunitrazepam, the central benzodiazepine receptor (CBR) ligand, binding to membranes of rat whole brain (IC50>10,000nM).
central benzodiazepine receptor Binding (binding) of in brain
18) Confidence 0.17 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321725 Disease Relevance 0.17 Pain Relevance 0.28
Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and met-enkephalin in normal rats.
Benzodiazepine receptor Binding (binding) of associated with narcan, enkephalin and morphine
19) Confidence 0.15 Published 1993 Journal Brain Res. Section Title Doc Link 8392430 Disease Relevance 0 Pain Relevance 1.08
SSR180575 shows high affinity (IC(50), 2.5-3.5 nM) and selectivity for the rat and human PBR and potently inhibits the in vivo binding of [(3)H]alpidem to PBR in the rat brain and spleen after oral or i.p. administration (ID(50), 0.1-0.3 mg/kg).
PBR Binding (binding) of in spleen
20) Confidence 0.11 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12023539 Disease Relevance 0.05 Pain Relevance 0.05

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