INT18088
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The absence of an increase in the MAC of halothane in the presence of flumazenil suggests that halothane does not interact with the benzodiazepine receptor, directly or indirectly, to produce its anesthetic action. | |||||||||||||||
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This raises the possibility that the presence of a social companion precludes the release of an endogenous anxiogen that binds to the benzodiazepine receptor. | |||||||||||||||
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In contrast to [11C]-(R)-PK11195, [11C]-DPA-713 is even able to show specific binding to the low basal expression levels of TSPO in control rats. | |||||||||||||||
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This higher uptake was shown to be selective TSPO binding. | |||||||||||||||
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Pyrazolopyrimidines display high affinity for the TSPO and two compounds from this class have already been radiolabeled for use in PET. | |||||||||||||||
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However, FG 7142 is less potent than RO 15-4513 and has less affinity for the benzodiazepine receptor (BZR). | |||||||||||||||
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The effects of a benzodiazepine receptor agonist and an antagonist on the MAC of halothane required to achieve anesthesia were evaluated to explore the possible functional interaction between halothane and the benzodiazepine receptor. | |||||||||||||||
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In naïve animals, PBR mRNA, protein expression and ligand binding are undetectable in the DRG. | |||||||||||||||
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The pyrazolopyrimidines DPA-713 and DPA-714 have higher affinity for the TSPO in vitro (Ki? | |||||||||||||||
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It was concluded that [11C]-DPA-713 is a specific ligand for the TSPO and that it may be useful for studying changes in the density of TSPO binding sites. | |||||||||||||||
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The apparent discrepancy between the results of our study and those of the previous studies in the striatum lesion model might be due to differences in the affinity state of the receptor between both animal models. [18F]-DPA-714 is an agonist of the TSPO and an agonist usually binds only to the high affinity state of the receptor. | |||||||||||||||
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PBR ligand binding also appears after injury in the superficial dorsal horn of the spinal cord. | |||||||||||||||
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SSR180575 shows high affinity (IC(50), 2.5-3.5 nM) and selectivity for the rat and human PBR and potently inhibits the in vivo binding of [(3)H]alpidem to PBR in the rat brain and spleen after oral or i.p. administration (ID(50), 0.1-0.3 mg/kg). | |||||||||||||||
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These include mediation via the GABA-benzodiazepine-ionophore complex, endogenous opioids, the hypothalamo-pituitary-adrenocortical axis and the noradrenergic system. | |||||||||||||||
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Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze. | |||||||||||||||
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Both constituents interact with a mitochondrial protein, the adenine nucleotide translocator, responsible for the ATP/ADP antiport and involved in mitochondrial membrane permeabilization. | |||||||||||||||
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These results indicate that the ability of alcohol to potentiate benzodiazepine-induced sedation is not simply an additive effect but may be related to the facilitation by alcohol of benzodiazepine receptor binding. | |||||||||||||||
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In contrast, DAA1097 and DAA1106 did not inhibit [3H]-flunitrazepam, the central benzodiazepine receptor (CBR) ligand, binding to membranes of rat whole brain (IC50>10,000nM). | |||||||||||||||
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Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and met-enkephalin in normal rats. | |||||||||||||||
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SSR180575 shows high affinity (IC(50), 2.5-3.5 nM) and selectivity for the rat and human PBR and potently inhibits the in vivo binding of [(3)H]alpidem to PBR in the rat brain and spleen after oral or i.p. administration (ID(50), 0.1-0.3 mg/kg). | |||||||||||||||
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General Comments
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