INT180885

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 12.52
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
Anatomy Link Frequency
fibroblasts 4
mesenchymal cells 2
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 69.60 Quite High
metalloproteinase 7 69.12 Quite High
cytokine 8 60.40 Quite High
fibrosis 3 33.12 Quite Low
imagery 8 20.28 Low Low
Sciatic nerve 8 13.32 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 655 99.84 Very High Very High Very High
Malignant Neoplastic Disease 43 99.84 Very High Very High Very High
Colon Cancer 1 99.72 Very High Very High Very High
Apoptosis 56 99.58 Very High Very High Very High
Breast Cancer 282 99.54 Very High Very High Very High
Metastasis 221 99.40 Very High Very High Very High
Adhesions 215 99.26 Very High Very High Very High
Recurrence 8 97.16 Very High Very High Very High
Osteolysis 112 96.36 Very High Very High Very High
Brain Tumor 1 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VCAN expression is elevated in our invasive Motif 1 NZM cells, which is in agreement with a recent report that VCAN is up-regulated in invasive human melanoma cells via a TCF4/AP1-mediated mechanism [37].
Positive_regulation (elevated) of Gene_expression (expression) of VCAN associated with melanoma
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.59 Pain Relevance 0.09
Data obtained in our study also indicate that adhesion fibroblasts may resist apoptosis due to anti apoptotic effects mediated by increased hMet1-e and CSPG2 levels and down regulation of IGFBP3.
Positive_regulation (increased) of Gene_expression (levels) of CSPG2 in fibroblasts associated with apoptosis and adhesions
2) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.32 Pain Relevance 0.06
As a recognized modulator of cell adhesion and motility for mesenchymal cells, increased versican expression in malignant derivatives appears to contribute towards a more aggressive phenotype [20,21].
Positive_regulation (increased) of Gene_expression (expression) of versican in mesenchymal cells associated with malignant neoplastic disease and adhesions
3) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.62 Pain Relevance 0.03
This was consistent with the observation of increased versican G3 expression as assessed by immunoblotting in the experimental group following tumor tissue harvest when compared to the vector control group (Figure 2c).


Positive_regulation (increased) of Gene_expression (expression) of versican associated with cancer
4) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.41 Pain Relevance 0
Versican expression has been shown to be a predictor of breast cancer survival in women and increased versican expression in the peri-tumoral matrix is correlated with a higher risk of cancer relapse [21].
Positive_regulation (increased) of Gene_expression (expression) of versican associated with cancer, breast cancer and recurrence
5) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.64 Pain Relevance 0
In vitro studies using conditioned media from breast cancer cell lines are able to upregulate versican expression of cancer derived and non-cancer derived mammary fibroblasts without an observed difference in basal level of versican synthesis or the degree of stimulation observed between the two fibroblast groups [21].
Positive_regulation (upregulate) of Gene_expression (expression) of versican in fibroblast associated with cancer and breast cancer
6) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.36 Pain Relevance 0
Versican expression may be important during the process of tumor bony invasion and subsequent remodeling of bone that leads to osteolysis.
Positive_regulation (important) of Gene_expression (expression) of Versican associated with cancer and osteolysis
7) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.33 Pain Relevance 0
Versican expression may also be important during the process of tumor bony invasion and subsequent remodeling of bone that leads to osteolysis with a resultant loss in mature organized bony micro-architecture.
Positive_regulation (important) of Gene_expression (expression) of Versican associated with cancer and osteolysis
8) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.89 Pain Relevance 0
Increased versican expression has been associated with local breast cancer invasiveness and a more aggressive tumor phenotype.
Positive_regulation (Increased) of Gene_expression (expression) of versican associated with cancer and breast cancer
9) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206723 Disease Relevance 0.71 Pain Relevance 0
Extracellular matrices that express high amounts of versican may function as modulators of cell proliferation and migration [32].
Positive_regulation (amounts) of Gene_expression (express) of versican
10) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.65 Pain Relevance 0

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