INT180894

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.00
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
Anatomy Link Frequency
fibroblasts 1
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 60.00 Quite High
fibrosis 9 42.88 Quite Low
Spinal cord 70 7.40 Low Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
pain pelvic 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 63 99.84 Very High Very High Very High
Apoptosis 52 99.14 Very High Very High Very High
Adhesions 383 98.04 Very High Very High Very High
Keloid Scars 25 93.80 High High
Wound Healing 15 92.68 High High
Contusions 44 87.84 High High
Severe Combined Immunodeficiency 30 86.08 High High
Injury 271 76.72 Quite High
Diphtheria 12 58.28 Quite High
Spinal Cord Injury 18 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They may also attain a high proliferating nature due to up regulation of S100A10 and CSPG2 genes, and down regulation of IGFBP3 (Table 2).
Regulation (regulation) of CSPG2
1) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.32 Pain Relevance 0.06
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Neg (no) Regulation (changes) of Versican
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.43 Pain Relevance 0
Further, biochemical analyses supplement stereological data and demonstrate no changes in Fibronectin, Versican, GFAP, NG2, and PE-CAM1 protein expression at 2 weeks post-transplant.
Neg (no) Regulation (changes) of Versican
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.15 Pain Relevance 0
Transcript levels of CSPG2 were not significantly altered by hypoxia.


Neg (not) Regulation (altered) of CSPG2 associated with hypoxia
4) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.84 Pain Relevance 0.03
Data obtained in our study also indicate that adhesion fibroblasts may resist apoptosis due to anti apoptotic effects mediated by increased hMet1-e and CSPG2 levels and down regulation of IGFBP3.
Regulation (regulation) of CSPG2 in fibroblasts associated with apoptosis and adhesions
5) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.27 Pain Relevance 0.06

General Comments

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