INT180895

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.45
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
Anatomy Link Frequency
osteoblasts 1
fibroblasts 1
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 77.16 Quite High
cytokine 8 60.40 Quite High
fibrosis 3 32.56 Quite Low
Sciatic nerve 3 25.80 Quite Low
backache 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 99.58 Very High Very High Very High
Prostate Cancer 3 99.40 Very High Very High Very High
Cancer 232 99.08 Very High Very High Very High
Adhesions 162 98.48 Very High Very High Very High
Breast Cancer 105 98.40 Very High Very High Very High
Malignant Neoplastic Disease 17 96.80 Very High Very High Very High
Wound Healing 5 93.56 High High
Ductal Carcinoma 6 91.88 High High
INFLAMMATION 5 77.16 Quite High
Metastasis 78 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data obtained in our study also indicate that adhesion fibroblasts may resist apoptosis due to anti apoptotic effects mediated by increased hMet1-e and CSPG2 levels and down regulation of IGFBP3.
Positive_regulation (increased) of CSPG2 in fibroblasts associated with apoptosis and adhesions
1) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.32 Pain Relevance 0.03
Four genes (SNAP25, KRT8, KRT18 and CDH2) were significantly decreased in degenerate human NP cells, while three genes (VCAN, TNMD and BASP1) were significantly increased in degenerate human AF cells.
Positive_regulation (increased) of VCAN
2) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Accumulation of versican in breast and prostate tumors appears to be a negative predictor of survival [21,22].
Positive_regulation (Accumulation) of versican associated with prostate cancer
3) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.66 Pain Relevance 0.03
Versican mRNA was prominent in osteoblasts and corresponded to localization of the protein.
Positive_regulation (prominent) of Versican in osteoblasts
4) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.90 Pain Relevance 0
Extracellular PG-M/versican has been observed to be elevated in a variety of human tumors including breast carcinoma [15,17-21].
Positive_regulation (elevated) of versican associated with cancer and breast cancer
5) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.58 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox