INT180920

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
lungs 2
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 100.00 Very High Very High Very High
fibrosis 60 98.36 Very High Very High Very High
Inflammation 27 48.64 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Sicca syndrome 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 67 99.76 Very High Very High Very High
Fibrosis 31 98.36 Very High Very High Very High
Pulmonary Fibrosis 34 97.76 Very High Very High Very High
Autoimmune Disease 3 90.84 High High
Cancer 5 90.04 High High
Interstitial Lung Diseases 6 79.52 Quite High
Pulmonary Disease 2 76.24 Quite High
Necrosis 3 60.56 Quite High
INFLAMMATION 28 48.64 Quite Low
Sprains And Strains 10 37.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, increased levels of TIMP protein and RNA are observed in lungs of patients with idiopathic pulmonary fibrosis, and TIMP expression there exceeds that of MMP [12].
Positive_regulation (increased) of Positive_regulation (levels) of TIMP in lungs associated with fibrosis and pulmonary fibrosis
1) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.66 Pain Relevance 0.28
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Positive_regulation (concentrations) of Positive_regulation (ratio) of TIMP associated with metalloproteinase and systemic sclerosis
2) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.94 Pain Relevance 0.18

General Comments

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