INT180925

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.21
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
PC-3 2
parenchyma 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 222 100.00 Very High Very High Very High
Inflammation 26 95.16 Very High Very High Very High
Osteoarthritis 19 92.24 High High
fibrosis 36 64.60 Quite High
rheumatoid arthritis 38 55.80 Quite High
cva 1 38.12 Quite Low
Arthritis 5 35.60 Quite Low
Inflammatory response 4 19.40 Low Low
depression 1 7.20 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 99.64 Very High Very High Very High
Cancer 249 98.44 Very High Very High Very High
Sprains And Strains 11 95.32 Very High Very High Very High
INFLAMMATION 29 95.16 Very High Very High Very High
Osteoarthritis 19 92.24 High High
Fibrosarcoma 2 90.08 High High
Disease 17 87.04 High High
Malignant Neoplastic Disease 2 86.68 High High
Skin Cancer 5 85.28 High High
Metastasis 53 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible explanation is that the increased release of MMP-2 in the inner lung parenchyma may result from downstream events caused by phagocyte activation and ROS production during inflammation.
Positive_regulation (increased) of Localization (release) of MMP-2 in parenchyma associated with inflammation
1) Confidence 0.54 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.31 Pain Relevance 0.14
Indeed, with increasing complexity of the model system, the importance of MMP-2 and MMP-9 became apparent.
Positive_regulation (increasing) of Localization (importance) of MMP-2 associated with metalloproteinase
2) Confidence 0.38 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.91 Pain Relevance 0.59
OSCC-3 cells co-cultured with EC-Bcl-2 showed significant increase in MMP2 secretion as compared to OSCC-3 cells co-cultured with EC-VC (Fig. 5A-B).
Positive_regulation (increase) of Localization (secretion) of MMP2
3) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.92 Pain Relevance 0
1 induced MMP-2 secretion in PC-3 prostate cancer cell lines.
Positive_regulation (induced) of Localization (secretion) of MMP-2 in PC-3 associated with reprotox - general 1
4) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 1.07 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox