INT180936

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CDIPT) endoplasmic reticulum (CDIPT) plasma membrane (CDIPT)
CDIPT (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 98.02 Very High Very High Very High
Infection 12 96.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 80 96.34 Very High Very High Very High
Disorder Of Lipid Metabolism 45 91.12 High High
Coronary Artery Disease 7 68.40 Quite High
Hyperlipidemia 27 61.16 Quite High
Lipodystrophy 2 54.60 Quite High
Insulin Resistance 5 53.84 Quite High
Sprains And Strains 8 22.32 Low Low
Hypersensitivity 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, viral isolates that are resistant to darunavir can be resistant in vitro to all other PIs except tipranavir.12 In clinical studies, patients who fail darunavir are more likely to preserve the activity of tipranavir than any other PI.33,35
Positive_regulation (resistant) of PIs
1) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724190 Disease Relevance 0 Pain Relevance 0
Although HIV infection itself is associated with above-normal triglyceride levels due to disease-related reduction in triglyceride clearance and increase in de-novo hepatic lipogenesis [9], some PIs exacerbate this lipid elevation by down-regulating low density lipoprotein (LDL)-receptor expression [10], interfering with the proteasome-mediated degradation of activated nuclear sterol regulatory element-binding protein-1 [11], and reducing triglyceride clearance further [12].
Positive_regulation (elevation) of PIs associated with acquired immune deficiency syndrome or hiv infection, disease and infection
2) Confidence 0.02 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC548524 Disease Relevance 1.43 Pain Relevance 0

General Comments

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