INT180956

Context Info Confidence 0.32 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0.04

peptidase activity (PLG, MMP13) extracellular space (PLG, MMP13) extracellular region (PLG, MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) plasma membrane (PLG)

PLG (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 46 86.96 Spinal cord 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 59 91.84 Osteoporosis 6 91.60 Reprotox - General 1 1 48.96 Skin Cancer 1 46.88 Cancer 18 29.60 Osteolysis 2 26.96 Hypercalcemia 7 5.00 Metastasis 3 5.00 Pain 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, we have shown that plasmin associated with the cell surface is responsible for activating the fibrillar collagenase, MMP-13.

plasmin Regulation (responsible) of Positive_regulation (activating) of MMP-13

1) Confidence 0.32 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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