INT180958

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1, PLAT) cytoplasm (F13A1, PLAT) peptidase activity (PLAT)
protein modification process (PLAT) extracellular space (PLAT) transferase activity, transferring acyl groups (F13A1)
F13A1 (Homo sapiens)
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 46 88.56 High High
ischemia 6 76.48 Quite High
Spinal cord 1 47.80 Quite Low
Pain 9 46.08 Quite Low
Angina 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 50 100.00 Very High Very High Very High
Diabetes Mellitus 80 89.12 High High
Myocardial Infarction 70 81.76 Quite High
Cancer 20 78.00 Quite High
Coronary Artery Disease 6 76.48 Quite High
Metabolic Syndrome 2 52.72 Quite High
Breast Cancer 59 50.00 Quite Low
Acute Coronary Syndrome 12 50.00 Quite Low
Hypercalcemia 7 47.16 Quite Low
Pain 9 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It might be speculated that altered fibrin in hyperglycemia leads to lower binding affinity of both tissue plasminogen activator and plasminogen toward fibrin (11) and, as a consequence, impaired clot lysis in our assay.
fibrin Binding (affinity) of tissue plasminogen activator associated with hyperglycemia
1) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.89 Pain Relevance 0.04
It might be speculated that altered fibrin in hyperglycemia leads to lower binding affinity of both tissue plasminogen activator and plasminogen toward fibrin (11) and, as a consequence, impaired clot lysis in our assay.
fibrin Binding (affinity) of tissue plasminogen activator associated with hyperglycemia
2) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.89 Pain Relevance 0.04
T-PA is thought to be more important in fibrinolysis, due to its fibrin binding capacity, whilst u-PA, especially when it is bound to its specific cell surface receptor (u-PAR), is thought to be involved in tissue remodelling and cell migration processes [7].
fibrin Binding (capacity) of T-PA
3) Confidence 0.01 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.38 Pain Relevance 0.39

General Comments

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