INT180967

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 138 99.96 Very High Very High Very High
Osteoarthritis 29 99.84 Very High Very High Very High
Pain 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 33 99.84 Very High Very High Very High
Breast Cancer 177 97.08 Very High Very High Very High
Osteoporosis 18 69.20 Quite High
Cancer 54 64.04 Quite High
Hypercalcemia 21 9.64 Low Low
Metastasis 9 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Osteolysis 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Skin Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During cartilage degeneration (that is, in osteoarthritis (OA)), the collagen matrix degrades and the GAG concentration diminishes, resulting in a severity-dependent decreased tonicity of between 280 and 350 mOsm [3,6].
Negative_regulation (diminishes) of Protein_catabolism (degrades) of collagen in cartilage associated with osteoarthritis
1) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.25 Pain Relevance 0.10
Degradation of collagen was abolished in plasminogen-depleted serum and could be restored by the addition of exogenous plasminogen.
Negative_regulation (abolished) of Protein_catabolism (Degradation) of collagen
2) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.62 Pain Relevance 0.22
Inhibitors of both the PAS (aprotinin and PA inhibitor-1) and MMPs (CT1166 and tisue inhibitor of metalloproteinase) blocked collagen degradation, demonstrating the requirement of both plasminogen activation and MMP activity for degradation.
Negative_regulation (blocked) of Protein_catabolism (degradation) of collagen associated with metalloproteinase
3) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.51 Pain Relevance 0.27
At the end of the culture period the media were centrifuged (15 min, 1200 × g) to remove any collagen fibrils, and radioactivity released during collagen degradation quantified by liquid scintillation counting.
Negative_regulation (released) of Protein_catabolism (degradation) of collagen
4) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.07 Pain Relevance 0

General Comments

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