INT180968

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 46 91.12 High High
Osteoarthritis 1 58.24 Quite High
Pain 3 57.52 Quite High
alcohol 14 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
nalbuphine 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 59 98.00 Very High Very High Very High
Toxicity 5 89.80 High High
Osteoporosis 6 80.56 Quite High
Osteoarthritis 1 58.24 Quite High
Arthralgia 1 57.52 Quite High
Shock 1 52.88 Quite High
Reprotox - General 1 2 37.92 Quite Low
Skin Cancer 1 35.84 Quite Low
Cancer 24 33.76 Quite Low
Osteolysis 2 15.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented in this paper clearly demonstrate that human breast carcinoma cell lines have the capacity to degrade the organic aspect of bone matrix in vitro, and there is a dependency on the PA system for the cell-mediated collagen degradation.
Regulation (dependency) of Protein_catabolism (degradation) of collagen associated with breast cancer
1) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.38 Pain Relevance 0.05
Several factors affect degradability of collagen, for example, structure contraction caused by cell penetration, collagenase, gelatinase and other non-specific proteinases can digest collagen [50].
Regulation (affect) of Protein_catabolism (degradability) of collagen
2) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956096 Disease Relevance 0.26 Pain Relevance 0.09

General Comments

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