INT180970

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.19

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 46 95.32 Spinal cord 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 59 83.64 Hypercalcemia 7 52.16 Osteoporosis 6 41.44 Cancer 18 20.64 Osteolysis 2 13.68 Metastasis 3 5.00 Reprotox - General 1 1 5.00 Pain 1 5.00 Disease 1 5.00 Skin Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has recently been demonstrated that binding of u-PA to its receptor increases pro-MMP-2,-9 [23] and -13 [16] activation, and that in the absence of cells, plasmin not only fails to activate pro-MMPs, but rapidly degrades them [23].

Positive_regulation (increases) of u-PA Binding (binding) of associated with metalloproteinase

1) Confidence 0.26 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.40 Pain Relevance 0.19

General Comments

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