INT180971

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 6.15
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
annulus 2
embryos 1
monocytes 1
neurons 1
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 123 100.00 Very High Very High Very High
Inflammation 184 99.82 Very High Very High Very High
cytokine 149 99.48 Very High Very High Very High
COX-2 inhibitor 4 99.08 Very High Very High Very High
agonist 77 98.00 Very High Very High Very High
Enkephalin 44 97.74 Very High Very High Very High
opioid receptor 226 92.52 High High
antagonist 37 90.88 High High
imagery 107 86.32 High High
Pain 264 84.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 90 100.00 Very High Very High Very High
INFLAMMATION 222 99.82 Very High Very High Very High
Intervertebral Disk Degeneration 18 99.76 Very High Very High Very High
Breast Cancer 177 99.62 Very High Very High Very High
Weight Gain 1 99.28 Very High Very High Very High
Toxicity 19 97.44 Very High Very High Very High
Choroideremia 166 96.24 Very High Very High Very High
Viral Meningitis 42 95.92 Very High Very High Very High
Weight Loss 3 95.36 Very High Very High Very High
Stress 69 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten months after the operation function was as follows: complete extension (Fig. 8), flexion to 90 degrees (Fig. 9), and a perfectly definite amount of abduction (Fig. 10).Fig. 7Preoperative roentgenogram showing definite protrusion of the acetabula, more marked on the left than on the right.Fig. 8 Fig. 9

 Fig. 10 

Protein_catabolism (degrees) of Fig
1) Confidence 0.77 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2635442 Disease Relevance 0.34 Pain Relevance 0.23
Target waiting times are almost achieved for urgent patients but at the expense of the less urgent.Fig. 10 Histogram of waiting times for MPS from the BNCS 2000 UK survey

Nature and quality of MPS in the UK

Protein_catabolism (quality) of Fig
2) Confidence 0.46 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.09 Pain Relevance 0.04
Interestingly, the depletion of plasminogen from serum also completely blocked breast cancer cell mediated collagen dissolution, implicating the PAS in breast cancer-mediated collagen degradation (Fig. 1).
Protein_catabolism (degradation) of Fig associated with breast cancer
3) Confidence 0.30 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.67 Pain Relevance 0.03
-stimulated breast cancer cell lines were cultured as a monolayer on either non-mineralized (Fig. 2A) or mineralized (Fig. 2B) bone matrix over a 24 h culture period there was significant degradation of the non-mineralized matrix (range 65–75%; Fig. 2A) and to a lesser extent the mineralized matrix (range 40–45%; Fig. 2B) only in the presence of plasminogen.
Protein_catabolism (degradation) of Fig associated with breast cancer
4) Confidence 0.30 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.53 Pain Relevance 0.06
-stimulated breast cancer cell lines were cultured as a monolayer on either non-mineralized (Fig. 2A) or mineralized (Fig. 2B) bone matrix over a 24 h culture period there was significant degradation of the non-mineralized matrix (range 65–75%; Fig. 2A) and to a lesser extent the mineralized matrix (range 40–45%; Fig. 2B) only in the presence of plasminogen.
Protein_catabolism (degradation) of Fig associated with breast cancer
5) Confidence 0.30 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.58 Pain Relevance 0.06
The increase in progressive motility (A + B grade cells) was accompanied by a concomitant decrease in both C and D grade cells (Fig. 4).


Protein_catabolism (grade) of Fig
6) Confidence 0.28 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.05 Pain Relevance 0.03
Indeed, normal weight gain was observed for both progrado and zangrado (Fig. 2) following treatment at 2000 mg/kg.
Protein_catabolism (zangrado) of Fig associated with weight gain
7) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.73 Pain Relevance 0
Following stimulation with Mycobacterium butyricum, large aggregates of Met-enkephalin-containing granules formed in submembranous regions and overall staining was significantly reduced as a sign of degranulation (Fig. 6D).
Protein_catabolism (degranulation) of Fig associated with enkephalin
8) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0 Pain Relevance 0.70
Thus, inhibition of COX-2 activity by NS398 suppresses the shear-induced, COX-2-dependent upregulation of these genes, which are primarily related to inflammation, matrix degradation and apoptosis (Fig. 5; Table 2; Table S3).
Protein_catabolism (degradation) of Fig associated with inflammation and apoptosis
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.34 Pain Relevance 0.13
As illustrated in Fig. 1D, inclusion of the COX-2 inhibitor NS398 did not affect DNA synthesis induced by 10 nM PGE2 or serum.
Protein_catabolism (illustrated) of Fig associated with cox-2 inhibitor
10) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.33 Pain Relevance 0.05
Among other substrates, these proteases exhibited degradation of casein and haemoglobin (Fig. 5).


Protein_catabolism (degradation) of Fig
11) Confidence 0.13 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.32 Pain Relevance 0
In agreement with the data summarized in Fig. 3, extracts from embryos irradiated with various energies and for different times collected at the MBT (st.8) exhibited levels of caspase activity below a control threshold and, therefore, were unable to trigger cyclin A2 cleavage (Fig. 4, top two panels).
Protein_catabolism (cleavage) of Fig in embryos
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813296 Disease Relevance 0 Pain Relevance 0
or proteasome abolished Tpl2 degradation (Fig. 2C).


Protein_catabolism (degradation) of Fig
13) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.47 Pain Relevance 0.17
Desensitization of the receptor (the progressive loss of receptor function), can be a consequence of multiple processes of receptor uncoupling, internalization, degradation and recycling.Adaptations of intracellular signalling mechanisms in opioid-sensitive neurons (Fig. 2).
Protein_catabolism (degradation) of Fig in neurons associated with opioid
14) Confidence 0.09 Published 2008 Journal Brain Section Body Doc Link PMC2367693 Disease Relevance 0 Pain Relevance 0.53
Change in the acidification of lysosomal environment of monocytes was measured by the change in fluorescence of pH-dependent BioParticles (Fig. 5A–C) and the rate of proteolytic degradation in lysosomes was measured using DQ-ovalbumin.
Protein_catabolism (degradation) of Fig in monocytes
15) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.58 Pain Relevance 0
B degradation (Fig. 4B) or JNK1/2 or p38 phosphorylation (supplementary Fig.
Protein_catabolism (degradation) of Fig
16) Confidence 0.07 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.26 Pain Relevance 0.26
B degradation (Fig. 4B) or JNK1/2 or p38 phosphorylation (supplementary Fig.
Protein_catabolism (degradation) of Fig
17) Confidence 0.07 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.27 Pain Relevance 0.26
The G219A mutant (GXG219D) in MCMJR1 also decreased its rate of proteolysis (Fig. 3D), suggesting that the role of this residue adjacent to the catalytic D220 might be similar to that reported for SPP and presenilin.


Protein_catabolism (proteolysis) of Fig
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0
receptor (sTNFR) reversed the effects on CD14 and CD40 expression in transwell cultures (Fig.
Protein_catabolism (transwell) of Fig
19) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
Fig. 2Dallas annulus disc degeneration grades [50]Fig. 3Dallas annulus disruption grades [50]Fig. 4Dallas grade 0 annulus disruptionFig. 5Dallas grade 1 annulus disruptionFig. 6Dallas grade 3 annulus disruption

Discography: complications

Protein_catabolism (grade) of Fig in annulus associated with intervertebral disk degeneration
20) Confidence 0.05 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.32 Pain Relevance 0.20

General Comments

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