INT180974

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.66
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL19) extracellular space (IL19) extracellular region (IL19)
Anatomy Link Frequency
MDA-MB-231 4
MCF-7 2
IL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 4 90.60 High High
cytokine 182 86.76 High High
metalloproteinase 46 75.96 Quite High
cINOD 6 15.36 Low Low
Inflammation 192 5.00 Very Low Very Low Very Low
antagonist 68 5.00 Very Low Very Low Very Low
chemokine 46 5.00 Very Low Very Low Very Low
COX-2 inhibitor 40 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 142 100.00 Very High Very High Very High
Breast Cancer 77 100.00 Very High Very High Very High
Asthma 630 99.80 Very High Very High Very High
Cancer 48 94.96 High High
Metastasis 5 53.72 Quite High
Skin Cancer 3 47.84 Quite Low
Ovarian Cancer 12 42.48 Quite Low
Hypercalcemia 7 34.68 Quite Low
INFLAMMATION 208 15.12 Low Low
Targeted Disruption 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the breast cancer cells (MDA-231, ZR-75-1 or MCF-7) were stimulated with TGF?
Positive_regulation (When) of Gene_expression (stimulated) of MDA in MCF-7 associated with breast cancer
1) Confidence 0.49 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.78 Pain Relevance 0.09
Celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants
Positive_regulation (induces) of Gene_expression (transfectants) of MDA in MDA-MB-231 associated with apoptosis
2) Confidence 0.49 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.10 Pain Relevance 0
These results suggest that celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants regardless of Bcl-2 expression.


Positive_regulation (induces) of Gene_expression (transfectants) of MDA in MDA-MB-231 associated with apoptosis
3) Confidence 0.49 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.69 Pain Relevance 0
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Positive_regulation (transfer) of Gene_expression (transfer) of IL-19 associated with asthma
4) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.54 Pain Relevance 0.21
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Positive_regulation (increased) of Gene_expression (expression) of IL-19 associated with asthma
5) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.54 Pain Relevance 0.19

General Comments

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