INT180975

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.12
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL19) extracellular space (IL19) extracellular region (IL19)
Anatomy Link Frequency
MDA-MB-231 12
MCF-7 3
IL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 97.76 Very High Very High Very High
COX-2 inhibitor 240 93.80 High High
adenocard 6 90.20 High High
cytokine 302 86.36 High High
metalloproteinase 46 74.76 Quite High
Inflammation 316 61.36 Quite High
antagonist 105 5.00 Very Low Very Low Very Low
chemokine 71 5.00 Very Low Very Low Very Low
agonist 62 5.00 Very Low Very Low Very Low
Inflammatory response 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 244 100.00 Very High Very High Very High
Metastasis 139 100.00 Very High Very High Very High
Asthma 945 99.60 Very High Very High Very High
Apoptosis 778 99.54 Very High Very High Very High
Depression 96 99.12 Very High Very High Very High
Osteolysis 12 99.04 Very High Very High Very High
INFLAMMATION 359 96.32 Very High Very High Very High
Ovarian Cancer 72 95.76 Very High Very High Very High
Cancer 332 94.96 High High
Retinoblastoma 27 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high-COX-2-expressing MDA-MB-231-E1A and MDA-MB-435-E1A cells were more sensitive to celecoxib (after 5 days of exposure to 0–60 ?
Gene_expression (expressing) of MDA in MDA-MB-231
1) Confidence 0.75 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.09 Pain Relevance 0
When the breast cancer cells (MDA-231, ZR-75-1 or MCF-7) were stimulated with TGF?
Gene_expression (stimulated) of MDA in MCF-7 associated with breast cancer
2) Confidence 0.65 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.77 Pain Relevance 0.07
These results suggest that celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants regardless of Bcl-2 expression.


Gene_expression (transfectants) of MDA in MDA-MB-231 associated with apoptosis
3) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.69 Pain Relevance 0
Celecoxib downregulates COX-2 protein expression in MDA-MB-231 and MDA-MB-435 cells
Gene_expression (expression) of MDA in MDA-MB-231
4) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.40 Pain Relevance 0.10
Evidence that nonsteroidal anti-inflammatory drugs can suppress COX-2 by transcriptional regulation [31] as well as suppressing both COX-2 and Bcl-2 protein expression [22,23] led us to investigate whether celecoxib would change the amount of COX-2 protein expressed by MDA-MB-231 and MDA-MB-435 cells.
Gene_expression (expressed) of MDA in MDA-MB-231 associated with inflammation and cinod
5) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.30 Pain Relevance 0.10
We showed that caspase-9 and PARP were activated, but caspase-8 was not activated, in celecoxib-treated MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants (Figure 3B).
Gene_expression (transfectants) of MDA in MDA-MB-231
6) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.60 Pain Relevance 0.11
MDA-MB-231-E1A cells (4 × 105) or MDA-MB-435-E1A cells (2 × 105) were plated in six-well plates in 2 ml of DMEM/F12, incubated for 24 h, and treated with celecoxib (0–40 ?
Gene_expression (plated) of MDA in MDA-MB-231
7) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.05 Pain Relevance 0
Survival of mice with MDA-MB-231 bone metastases was improved with HIF-1?
Gene_expression (improved) of MDA in MDA-MB-231 associated with metastasis
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.68 Pain Relevance 0
For the MTT assay, cells were plated in 96-well plates (1.2 × 104 cells/well for MDA-MB-231 cells or 8.0 × 103 cells/well for MDA-MB-435, MCF-7, and SKOV3.ip1 cells) in 80 ?
Gene_expression (/) of MDA in MDA-MB-231
9) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.13 Pain Relevance 0
Celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants
Gene_expression (transfectants) of MDA in MDA-MB-231 associated with apoptosis
10) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.10 Pain Relevance 0
Haplotype analysis of the IL10, IL19, IL20, and IL24 genes was performed according to the pairwise linkage disequilibrium pattern observed within each of these genes (cases + controls, n = 429).
Gene_expression (analysis) of IL19
11) Confidence 0.62 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.28 Pain Relevance 0
The results are in agreement with previous studies which reported a 1.4-fold increase in invasiveness in S100A7-overexpressing MDA-MB-231 clones [28].
Gene_expression (overexpressing) of MDA in MDA-MB-231
12) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.78 Pain Relevance 0.03
The two COX-2-overexpressing cell lines MDA-MB-231-E1A and MDA-MB-435-E1A were more sensitive to celecoxib than the corresponding control cells, but the two low-COX-2-expressing cell lines MCF-7-E1A and SKOV3.ip1-E1A were no more sensitive than control cells to celecoxib.
Gene_expression (overexpressing) of MDA in MDA-MB-231
13) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206712 Disease Relevance 0.85 Pain Relevance 0
We showed that the celecoxib-sensitive MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants originally overexpressed COX-2, and they produced less COX-2 protein in the presence of celecoxib (Figures 1 and 4A).
Gene_expression (transfectants) of MDA in MDA-MB-231
14) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.28 Pain Relevance 0.12
If the COX-2 expression level of the MDA-MB-231-E1A stable transfectants is considered to be 100%, the relative percentage COX-2 expression for each stable transfectant is as follows: MDA-MB-435-E1A, 78%; SKOV3.ip1-E1A, 6%; and MCF-7-E1A, 6%.
Gene_expression (expression) of MDA in MCF-7
15) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.23 Pain Relevance 0
We first established the cytotoxicity of celecoxib in two COX-2-overexpressing E1A-transfected breast cancer cell lines (MDA-MB-231 and MDA-MB-435) and in two low-COX-2-expressing E1A-transfected cell lines (MCF-7 (breast cancer) and SKOV3.ip1 (ovarian cancer)).
Gene_expression (overexpressing) of MDA in MCF-7 associated with ovarian cancer and breast cancer
16) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206712 Disease Relevance 0.92 Pain Relevance 0
The selected SNPs of block 1 were rs2243188 and rs2243193 of IL19 (intron 6, 3' UTR) and rs2981572 of IL20 (5' near gene) and SNPs of block 2 were rs1518108 of IL20 (3' UTR), rs1150253 and rs1150258 of IL24 (intron 2, exon 5).
Gene_expression (rs1518108) of IL19
17) Confidence 0.54 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.33 Pain Relevance 0
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Gene_expression (expression) of IL-19 associated with asthma
18) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.54 Pain Relevance 0.19
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Gene_expression (expression) of IL-19 associated with asthma
19) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.21
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Gene_expression (transfer) of IL-19 associated with asthma
20) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.54 Pain Relevance 0.21

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