INT180984

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.13
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL8) DNA binding (IRF6) cytoplasm (IRF6)
cytosol (IRF6) extracellular space (IL8) signal transduction (IL8)
Anatomy Link Frequency
neutrophils 6
amnion 2
nasal 2
corneal epithelial cells 2
IRF6 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 618 99.24 Very High Very High Very High
narcan 30 96.96 Very High Very High Very High
opioid receptor 126 86.36 High High
antagonist 7 84.40 Quite High
Inflammatory response 32 80.28 Quite High
Inflammation 104 66.32 Quite High
Inflammatory stimuli 5 66.24 Quite High
cytokine 76 62.00 Quite High
Opioid 18 32.08 Quite Low
Codeine 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 142 95.68 Very High Very High Very High
Infection 77 92.48 High High
Neonatal Necrotizing Enterocolitis 68 91.36 High High
Systemic Inflammatory Response Syndrome 21 80.64 Quite High
Nicotine Addiction 6 80.56 Quite High
Hypersensitivity 6 79.28 Quite High
Apoptosis 10 78.40 Quite High
Injury 21 69.44 Quite High
Herpes Simplex Virus 2 67.20 Quite High
Colon Cancer 2 66.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the LPS-induced increase in nasal IL-8 release by Prolastin
LPS Positive_regulation (increase) of Localization (release) of IL-8 in nasal
1) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.16 Pain Relevance 0
Compared to controls LPS significantly increased the release of IL-8 (32±3 ng/106 neutrophils ±SD, n?
LPS Positive_regulation (increased) of Localization (release) of IL-8 in neutrophils
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0 Pain Relevance 1.02
Morphine concentrations equivalent to those found in the serum of septic patients significantly inhibited LPS-induced IL-8 secretion in neutrophils.



LPS Positive_regulation (induced) of Localization (secretion) of IL-8 in neutrophils associated with morphine
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808358 Disease Relevance 0.65 Pain Relevance 0.95
The effects of the concentration of morphine found in serum of septic patients on LPS-induced release of IL-8 by human neutrophils were tested.


LPS Positive_regulation (induced) of Localization (release) of IL-8 in neutrophils associated with morphine
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808358 Disease Relevance 0.36 Pain Relevance 1.35
The absence of LPS-stimulated IL-8 release on the amniotic side of the membranes is in contrast to an earlier report showing that LPS increases IL-8 secretion from isolated amnion cells as well as from decidual cells [31]: these differences in response could reflect differences between cell and intact tissue cultures.
LPS Positive_regulation (increases) of Localization (secretion) of IL-8 in amnion
5) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.12 Pain Relevance 0.12
A more recent report showed that the addition of tear LBP and CD14 were required for LPS-stimulated IL-6 and IL-8 secretion in corneal epithelial cells [22].
LPS Positive_regulation (stimulated) of Localization (secretion) of IL-8 in corneal epithelial cells
6) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.19 Pain Relevance 0
These results indicate that LPS could stimulate IEC secretion of IL-8, but only if TLR4 expression was first induced by treating the cells with PAF and later stimulated with TLR4 ligand.
LPS Positive_regulation (stimulate) of Localization (secretion) of IL-8
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.14 Pain Relevance 0
Furthermore, priming with PAF directly led to enhanced LPS-induced IL-8 secretion, thus showing the functional effect of increased TLR4 expression.
LPS Positive_regulation (induced) of Localization (secretion) of IL-8
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.50 Pain Relevance 0.03

General Comments

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