INT181001

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.07
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 55 99.64 Very High Very High Very High
Pain 8 98.56 Very High Very High Very High
Inflammatory response 7 97.44 Very High Very High Very High
spinal inflammation 110 96.04 Very High Very High Very High
rheumatoid arthritis 247 96.00 Very High Very High Very High
Arthritis 10 94.88 High High
cytokine 18 94.56 High High
Infliximab 162 94.36 High High
Osteoarthritis 93 94.04 High High
chemokine 4 94.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 99.64 Very High Very High Very High
Arthralgia 2 98.56 Very High Very High Very High
Arthritis 9 97.92 Very High Very High Very High
Low Back Pain 110 96.04 Very High Very High Very High
Rheumatoid Arthritis 247 96.00 Very High Very High Very High
Inflammatory Bowel Disease 118 95.68 Very High Very High Very High
Polymyositis 2 95.56 Very High Very High Very High
Seronegative Spondarthritis 3 94.88 High High
Osteoarthritis 4 94.04 High High
Disease 141 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agreement between the five ACPA assays and RF in population 2
Regulation (Agreement) of ACPA
1) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 1.10 Pain Relevance 0.50
The target of these ANCA was identified by ELISA as proteinase 3 for two sera (25 and 40 AU/ml) and both myeloperoxidase and proteinase 3 for one serum (45 and 30 AU/ml).
Regulation (target) of ANCA
2) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.40 Pain Relevance 1.13
The target of these ANCA was neither proteinase 3 nor myeloperoxidase.
Regulation (target) of ANCA
3) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.22 Pain Relevance 1.03
These studies therefore further support a central role of serpins in inflammation, not only as the regulators of proteinase activity, but also as the suppressers of endotoxin induced pro-inflammatory responses.
Regulation (regulators) of proteinase associated with inflammatory response and inflammation
4) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.63 Pain Relevance 0.43
Because the regulation and biologic function of a number of these serine proteinase inhibitors remains incompletely defined, our analyses provide further rationale for their continued study.


Spec (analyses) Regulation (regulation) of proteinase
5) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906814 Disease Relevance 0.53 Pain Relevance 0.29
For instance, both ASCA and pANCA were found to be less sensitive in Chinese and Japanese patients, while the positivity of pANCA was shown to be higher in Mexican-American UC patients.22,23
Regulation (sensitive) of pANCA associated with inflammatory bowel disease
6) Confidence 0.00 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.18 Pain Relevance 0

General Comments

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