INT181003

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.93
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
platelets 2
neural 2
neutrophils 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 14 99.58 Very High Very High Very High
aspirin 9 99.20 Very High Very High Very High
Calcitonin gene-related peptide 13 99.12 Very High Very High Very High
Inflammation 64 98.20 Very High Very High Very High
COX-2 inhibitor 3 95.04 Very High Very High Very High
Neuropeptide 2 95.04 Very High Very High Very High
Glutamate receptor 15 90.56 High High
Glutamate 43 87.92 High High
Inflammatory response 13 79.48 Quite High
antagonist 7 71.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 82 98.20 Very High Very High Very High
Influenza Virus Infection 44 95.08 Very High Very High Very High
Infection 31 94.36 High High
Cancer 28 93.56 High High
Disorder Of Lipid Metabolism 3 85.36 High High
Fibrosarcoma 9 77.56 Quite High
Thrombosis 28 71.84 Quite High
Hemorrhage 1 66.28 Quite High
Obesity 25 54.32 Quite High
Neurodegenerative Disease 4 53.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, caffeine mediated block of Iglu was rapid, developing in tens of milliseconds (Fig. 3), or ?
Negative_regulation (developing) of Localization (milliseconds) of Fig
1) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0.31
Under control conditions, hESCs can be readily converted to neural cells over 16 days (Fig. 1A) with concomitant loss of pluripotency markers OCT4 and NANOG, and up regulation of neural progenitor markers MUSASHI (D8) and SOX1 (D 16).
Negative_regulation (loss) of Localization (regulation) of Fig in neural
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0.10 Pain Relevance 0.04
M AA with increasing concentrations of EPA, DPA or DHA for 24 h did not diminish or increase the secretion of MMP-9 (Fig. 3).
Neg (not) Negative_regulation (diminish) of Localization (secretion) of Fig
3) Confidence 0.13 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
PO at 12.5 µg/ml significantly reduced not only the level of the secretion (Fig. 5B) its but also the expression of VEGF (Fig. 5C).
Negative_regulation (reduced) of Localization (secretion) of Fig
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.45 Pain Relevance 0.03
The fact that there is such abundant expression of endogenous Rab5 in HEK.hIP cells may explain why Rab5aS34N did not result in a more substantial inhibition of internalization of the hIP (Fig. 1F).
Negative_regulation (inhibition) of Localization (internalization) of Fig
5) Confidence 0.10 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0
mol/l) led to significantly decreased RBP4 release into the media (139 ng/ml [130.9–154.7] vs. 168 ng/ml [141.4–220], deferoxamine versus vehicle, respectively; P = 0.02) (Fig. 5C).
Negative_regulation (decreased) of Localization (release) of Fig
6) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.19 Pain Relevance 0
The number of PS-exposing platelets was greatest at low shear, and was reduced in the presence of hirudin (Fig. 2F).
Negative_regulation (reduced) of Localization (presence) of Fig in platelets
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.07 Pain Relevance 0
Prolastin inhibited IL-8 release by neutrophils stimulated with opsonized zymosan (Fig 3A).
Negative_regulation (inhibited) of Localization (release) of Fig in neutrophils
8) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.03
While a 50% decrease in Her2 in C-81 led to a similar decrease in PSA secretion (Fig. 5B, lanes 1 and 2).
Negative_regulation (decrease) of Localization (secretion) of Fig
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Results showed that IV-triggered PGE2 release (Fig. 5A) and IL-32 (Fig. 5B) production in the culture supernatants were inhibited by either NS398 or Aspirin, which indicated that IL-32 is an important pro-inflammatory factor downstream of COX-2 during influenza A virus infection.


Negative_regulation (inhibited) of Localization (release) of Fig associated with aspirin, inflammation, influenza virus infection and infection
10) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.12 Pain Relevance 0.36
CGRP increases somatostatin release, indirectly decreasing gastrin and acid secretion (Fig. 1A).
Negative_regulation (decreasing) of Localization (secretion) of Fig associated with somatostatin and calcitonin gene-related peptide
11) Confidence 0.03 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.45

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