INT181017

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 13
Disease Relevance 9.82
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctss) lysosome (Ctss)
Anatomy Link Frequency
spinal cord 2
microglia 2
spinal 1
macrophages 1
brain 1
Ctss (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 255 100.00 Very High Very High Very High
Spinal cord 186 99.68 Very High Very High Very High
Lasting pain 38 99.20 Very High Very High Very High
Neuropathic pain 202 99.10 Very High Very High Very High
Pain 112 98.00 Very High Very High Very High
medulla 16 97.40 Very High Very High Very High
dorsal root ganglion 18 95.96 Very High Very High Very High
Central nervous system 10 94.12 High High
Peripheral nerve injury 16 91.24 High High
chemokine 49 90.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 347 100.00 Very High Very High Very High
Injury 527 99.88 Very High Very High Very High
Pain 160 99.20 Very High Very High Very High
Nervous System Injury 72 99.20 Very High Very High Very High
Neuropathic Pain 274 99.10 Very High Very High Very High
Disease 26 96.04 Very High Very High Very High
Ganglion Cysts 18 95.96 Very High Very High Very High
Motor Neuron Diseases 8 95.24 Very High Very High Very High
Adhesions 2 91.48 High High
Hyperalgesia 24 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of CATS and CATX protein levels and increase in enzyme activities
Gene_expression (levels) of CATS
1) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.16 Pain Relevance 0.10
In the current study we analysed the participation of two cysteine proteases, the CATS and CATX, in the molecular processes underlying the induction and maintenance of neuropathic pain.
Spec (analysed) Gene_expression (participation) of CATS associated with neuropathic pain
2) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.42 Pain Relevance 0.41
Cellular and spatiotemporal expression of CATS and CATX in normal and L5T spinal cord
Gene_expression (expression) of CATS in spinal cord associated with spinal cord
3) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.67 Pain Relevance 0.65
Therefore, we first analyzed the protein levels of CATX and CATS in the spinal cord of sham versus L5T animals at 8 d after injury, a time point when the increase in immunoreactivities in the spinal cord was at its maximum (Fig. 3).
Spec (analyzed) Gene_expression (levels) of CATS in spinal cord associated with injury and spinal cord
4) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.18 Pain Relevance 0.16
Our immunohistochemical analysis, following the temporal development of neuropathic pain, supports the view that the upregulation of CATS and CATX expression is dynamic and proceeds along the fasciculus gracilis up to the medulla oblongata.
Gene_expression (expression) of CATS in medulla oblongata associated with medulla and neuropathic pain
5) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.84 Pain Relevance 0.58
Both, CATS and CATX, are widely expressed in the brain [26] and have been implicated in several neurological conditions such as Alzheimer's disease [26,37,38], amyotrophic lateral sclerosis [26,27] and age-related inflammation [26].
Gene_expression (expressed) of CATS in brain associated with inflammation, disease and motor neuron diseases
6) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.88 Pain Relevance 0.60
This characteristic spatio-temporal pattern suggests that the upregulation of CATS/X expression accompanies the degenerative process of the transected axons [41].
Gene_expression (expression) of CATS
7) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.46 Pain Relevance 0.43
The cellular distribution and the spatio-temporal development of the altered expression of CATS and CATX suggest that these proteins are important players in the spinal mechanisms involved in chronic pain induction and maintenance.



Gene_expression (expression) of CATS in spinal associated with lasting pain
8) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2527007 Disease Relevance 0.46 Pain Relevance 0.66
In situ hybridization studies in the wild-type wound show Cathepsin S to be expressed by macrophages clustered around the wound site, but also by cells in the dermis at skin sites well away from the wound (data not shown), suggesting that it is constitutively expressed by cells of the monocyte lineage, rather than being part of the macrophage activation profile.
Gene_expression (expressed) of Cathepsin S in macrophages associated with injury
9) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.97 Pain Relevance 0.21
No expression of Cathepsin S is seen in wounded or unwounded skin of the macrophageless PU.1 null mouse (Figure 7Bb,c).
Gene_expression (expression) of Cathepsin S in skin
10) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.99 Pain Relevance 0.20
Cathepsin S is a typical gene of the late inflammatory cluster, being highly upregulated at 24 hours post-wounding in the wild-type, but with no expression in the PU.1 null wound (Figure 7Ba).
Neg (no) Gene_expression (expression) of Cathepsin S associated with inflammation and injury
11) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.04 Pain Relevance 0.32
A recent study shows that cysteine protease cathepsin S (CatS), which is produced in microglia after nerve injury, can enhance neuropathic pain by cleavage of FKN on the membrane of DRG neurons.
Gene_expression (produced) of cathepsin S in microglia associated with dorsal root ganglion, nervous system injury and neuropathic pain
12) Confidence 0.18 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.36 Pain Relevance 0.94
A recent study shows that cysteine protease cathepsin S (CatS), which is produced in microglia after nerve injury, can enhance neuropathic pain by cleavage of FKN on the membrane of DRG neurons.
Gene_expression (produced) of cathepsin S in microglia associated with dorsal root ganglion, nervous system injury and neuropathic pain
13) Confidence 0.16 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.36 Pain Relevance 0.94

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