INT181020

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Sfpi1) nucleus (Sfpi1) DNA binding (Sfpi1)
Anatomy Link Frequency
neutrophil 2
Sfpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 92 99.54 Very High Very High Very High
chemokine 17 87.44 High High
cytokine 26 27.04 Quite Low
fibrosis 11 14.04 Low Low
Inflammatory response 26 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 163 99.76 Very High Very High Very High
INFLAMMATION 117 99.54 Very High Very High Very High
Rhinitis 11 84.68 Quite High
Apoptosis 77 50.00 Quite Low
Wound Healing 10 50.00 Quite Low
Disease 20 32.88 Quite Low
Hypersensitivity 15 32.52 Quite Low
Keloid Scars 2 14.56 Low Low
Fibrosis 14 14.04 Low Low
Asthma 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PU.1 expression level determines the fate of the cell and is necessary for dictating monocyte/macrophage and dendritic cell commitment and differentiation, as well as for neutrophil differentiation.
Positive_regulation (necessary) of Gene_expression (expression) of PU.1 in neutrophil
1) Confidence 0.67 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.08 Pain Relevance 0
Cathepsin S is a typical gene of the late inflammatory cluster, being highly upregulated at 24 hours post-wounding in the wild-type, but with no expression in the PU.1 null wound (Figure 7Ba).
Positive_regulation (upregulated) of Neg (no) Gene_expression (expression) of PU.1 associated with inflammation and injury
2) Confidence 0.45 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.02 Pain Relevance 0.31

General Comments

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