INT181022

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.69
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
macrophages 2
T cells 2
diaphragm 1
extracellular matrix 1
lung 1
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 507 99.74 Very High Very High Very High
cytokine 189 99.36 Very High Very High Very High
Multiple sclerosis 310 98.48 Very High Very High Very High
Inflammation 446 97.60 Very High Very High Very High
Central nervous system 158 95.12 Very High Very High Very High
antagonist 72 94.36 High High
ischemia 52 90.96 High High
anesthesia 9 60.28 Quite High
fibrosis 14 58.88 Quite High
Inflammatory response 55 57.12 Quite High
Disease Link Frequency Relevance Heat
Infection 81 99.26 Very High Very High Very High
Asthma 84 99.20 Very High Very High Very High
Multiple Sclerosis 375 99.04 Very High Very High Very High
Endotoxemia 57 98.64 Very High Very High Very High
Injury 521 97.80 Very High Very High Very High
INFLAMMATION 510 97.60 Very High Very High Very High
Myositis 5 96.88 Very High Very High Very High
Adhesions 52 96.80 Very High Very High Very High
Hypersensitivity 13 96.72 Very High Very High Very High
Frailty 15 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
CCR1 Binding (ligands) of
1) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.90 Pain Relevance 0.39
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
CCR1 Binding (ligands) of in lung associated with endotoxemia and infection
2) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.72 Pain Relevance 0.22
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
RANTES Binding (ligands) of in diaphragm
3) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
RANTES Binding (ligands) of
4) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.84 Pain Relevance 0.39
, MCP-1) and molecules involved in extracellular matrix digestion (e.g., MMP-9) as well as its own receptor, CCR1 [46].
CCR1 Binding (receptor) of in extracellular matrix
5) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.41 Pain Relevance 0.47
For example, the gene for chemokine receptor 1 (CCr1), a receptor for several chemokines including MIP-1?
CCr1 Binding (receptor) of associated with chemokine
6) Confidence 0.33 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.07 Pain Relevance 0.39
CCR1 positive T cells have been shown to be associated with IL-13 release [24] and Th2 cells are known to be the main source of IL-5 in allergic airway inflammation [27].
CCR1 Binding (associated) of in T cells associated with inflammation and hypersensitivity
7) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.50 Pain Relevance 0.35
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
RANTES Binding (ligands) of
8) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.67 Pain Relevance 0.66
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
CCR1 Binding (ligands) of
9) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.67 Pain Relevance 0.66
In later stages, macrophages became CCR1-/CCR5+, while microglia upregulated CCR5.
CCR1 Binding (macrophages) of in macrophages
10) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.75 Pain Relevance 0.28
Experimental evidence now suggests that CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8 and CXCR3 on hematogenous mononuclear cells recognize these chemoattractant and regulatory molecules to induce cell differentiation, adhesion or migration of distinct inflammatory cells in peripheral lymphoid organs, at the BBB and in the CNS during the course of EAE.
CCR1 Binding (recognize) of in mononuclear cells associated with multiple sclerosis, inflammation, central nervous system and adhesions
11) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.05 Pain Relevance 0.27
Neutralization of the CCR1 ligand CCL3 (MIP-1?)
CCR1 Binding (ligand) of
12) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.07 Pain Relevance 0.37
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCR1 Binding (associated) of in T cells associated with chemokine and multiple sclerosis
13) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.93 Pain Relevance 0.33
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCR1 Binding (associated) of in macrophages associated with chemokine and multiple sclerosis
14) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.93 Pain Relevance 0.33
, RANTES, and eotaxin antibodies (R&D Systems, Minneapolis, MN) that detect protein at concentrations greater than 10 pg/ml and do not crossreact with any other cytokines.


RANTES Neg (not) Binding (crossreact) of associated with cytokine
15) Confidence 0.04 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

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