INT181032

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.96
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf7) extracellular region (Fgf7) Golgi apparatus (Fgf7)
Anatomy Link Frequency
fibroblasts 3
keratinocytes 3
glial cell 1
skin 1
connective tissue 1
Fgf7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 193 100.00 Very High Very High Very High
chemokine 67 98.20 Very High Very High Very High
Inflammation 312 81.52 Quite High
Inflammatory response 67 80.08 Quite High
psoriasis 47 23.72 Low Low
rheumatoid arthritis 92 20.56 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
fibrosis 30 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 36 99.32 Very High Very High Very High
Injury 607 99.00 Very High Very High Very High
Hypersensitivity 5 98.80 Very High Very High Very High
Wound Healing 148 94.36 High High
Fibrosis 32 93.80 High High
Systemic Sclerosis 34 91.52 High High
Targeted Disruption 52 88.28 High High
Cancer 15 86.96 High High
Necrosis 9 86.48 High High
Congenital Anomalies 31 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently reported that expression of FGF7 and FGF10 increases in the dermal papilla during the transition from early to late telogen.
Gene_expression (expression) of FGF7 in papilla
1) Confidence 0.61 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.33 Pain Relevance 0.03
For example, exposure of keratinocytes to keratinocyte growth factor (KGF) in vitro reveals many of the early and late effector genes that are expressed by keratinocytes at the wound edge [22].
Gene_expression (expressed) of KGF in keratinocytes associated with injury
2) Confidence 0.58 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.82 Pain Relevance 0.09
The responsible ligands are most likely FGF1, FGF7, FGF10, and FGF22, which are expressed in different compartments of the skin (Steiling and Werner, 2003).
Gene_expression (expressed) of FGF7 in skin
3) Confidence 0.48 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.22 Pain Relevance 0.04
Together with FGF7, they can activate the “b” splice variants of FGFRs 1 and 2 (Zhang et al., 2006) that are expressed in keratinocytes (Beer et al., 2000; Zhang et al., 2004).
Gene_expression (expressed) of FGF7 in keratinocytes
4) Confidence 0.48 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.54 Pain Relevance 0
Our data showed that BM-MSCs secreted differential levels of numerous cytokines than dermal fibroblasts, such as significantly greater amounts of EGF, KGF, IGF-1, VEGF-?
Gene_expression (amounts) of KGF in fibroblasts associated with cytokine
5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.91 Pain Relevance 0.33
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Gene_expression (expression) of FGF7 in connective tissue associated with hypersensitivity and cytokine
6) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.14 Pain Relevance 0.10
For example, exposure of keratinocytes to keratinocyte growth factor (KGF) in vitro reveals many of the early and late effector genes that are expressed by keratinocytes at the wound edge [22].
Gene_expression (expressed) of keratinocyte growth factor in keratinocytes associated with injury
7) Confidence 0.24 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.88 Pain Relevance 0.09
Real-Time PCR analysis of expression levels of growth factors and chemokines in BM-MSCs and dermal fibroblasts treated under hypoxic conditions revealed that BM-MSCs expressed significantly greater amounts of several growth factors including epidermal growth factor (EGF, 15 fold), keratinocyte growth factor (KGF, 21 fold), insulin-like growth factor-1 (IGF-1, 49 fold), vascular endothelial growth factor-?
Gene_expression (expressed) of keratinocyte growth factor in fibroblasts associated with chemokine and hypoxia
8) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.32 Pain Relevance 0.12
Fifteen cytokines at differential expression levels were found; of them 13 cytokines were apparently higher in BM-MSC-conditioned medium including EGF, KGF, IGF-1, glial cell line-derived neurotrophic factor (GDNF), platelet derived growth factor-BB (PDGF-BB), VEGF-?
Gene_expression (expression) of KGF in glial cell associated with cytokine
9) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.47 Pain Relevance 0.47
Real-Time PCR analysis of expression levels of growth factors and chemokines in BM-MSCs and dermal fibroblasts treated under hypoxic conditions revealed that BM-MSCs expressed significantly greater amounts of several growth factors including epidermal growth factor (EGF, 15 fold), keratinocyte growth factor (KGF, 21 fold), insulin-like growth factor-1 (IGF-1, 49 fold), vascular endothelial growth factor-?
Gene_expression (expressed) of KGF in fibroblasts associated with chemokine and hypoxia
10) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.33 Pain Relevance 0.12

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