INT181040

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctss) lysosome (Ctss)
Ctss (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 78 100.00 Very High Very High Very High
chemokine 13 90.52 High High
Pain 10 86.56 High High
Dorsal horn 3 81.92 Quite High
medulla 2 75.00 Quite High
Neuropathic pain 10 69.36 Quite High
cytokine 3 67.28 Quite High
Spinal cord 19 58.36 Quite High
allodynia 4 48.68 Quite Low
Hyperalgesia 2 48.12 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 104 100.00 Very High Very High Very High
Injury 165 99.28 Very High Very High Very High
Pain 14 86.56 High High
Neuropathic Pain 17 69.36 Quite High
Wound Healing 10 50.00 Quite Low
Hyperalgesia 2 48.12 Quite Low
Motor Neuron Diseases 1 43.68 Quite Low
Disease 3 42.00 Quite Low
Gastritis 2 26.40 Quite Low
Multiple Trauma 1 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This characteristic spatio-temporal pattern suggests that the upregulation of CATS/X expression accompanies the degenerative process of the transected axons [41].
Positive_regulation (upregulation) of Gene_expression (expression) of CATS
1) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.47 Pain Relevance 0.43
Cathepsin S is a typical gene of the late inflammatory cluster, being highly upregulated at 24 hours post-wounding in the wild-type, but with no expression in the PU.1 null wound (Figure 7Ba).
Positive_regulation (upregulated) of Neg (no) Gene_expression (expression) of Cathepsin S associated with inflammation and injury
2) Confidence 0.24 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.04 Pain Relevance 0.32

General Comments

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