INT181042

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.34
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
saliva 2
macrophage 1
plasma 1
brain 1
T cells 1
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 621 100.00 Very High Very High Very High
cytokine 207 99.90 Very High Very High Very High
Inflammation 330 99.62 Very High Very High Very High
rheumatoid arthritis 20 97.04 Very High Very High Very High
antagonist 22 94.16 High High
imagery 5 93.60 High High
ischemia 56 90.76 High High
Inflammatory response 64 86.88 High High
agonist 17 86.16 High High
psoriasis 18 85.60 High High
Disease Link Frequency Relevance Heat
Disease 162 99.80 Very High Very High Very High
INFLAMMATION 423 99.62 Very High Very High Very High
Malaria 192 98.82 Very High Very High Very High
Cancer 40 97.52 Very High Very High Very High
Rheumatoid Arthritis 20 97.04 Very High Very High Very High
Cerebral Malaria 156 96.96 Very High Very High Very High
Frailty 4 96.64 Very High Very High Very High
Chlamydia Infection 138 95.96 Very High Very High Very High
Myositis 1 95.84 Very High Very High Very High
Injury 337 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether RANTES and its receptor interactions were localized (brain) or systemic (peripheral blood), plasma RANTES levels were determined in P. yoelii 17XL-infected and control mice, using RANTES specific ELISA (Biosource International, Camarillo, CA, USA) according to the manufacturer's specifications.
RANTES Binding (interactions) of in plasma
1) Confidence 0.41 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.05 Pain Relevance 0.05
The pattern of CCL5 and CCR5 as well as IFN-?
CCL5 Binding (pattern) of
2) Confidence 0.35 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.96 Pain Relevance 0.15
Our data suggest that CCL5 interactions are comparably important and mediate the temporal recruitment and activation of T cells to mitigate chlamydial infection through protective mucosal adaptive immunity by enhancing Th1 >> Th2 humoral and cellular immune responses.
CCL5 Binding (interactions) of in T cells associated with chlamydia infection
3) Confidence 0.35 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.70 Pain Relevance 0.17
Indeed, trafficking of inflammatory Th1 cells into the brain was reportedly mediated largely by RANTES interaction with CCR5 receptor [30].
RANTES Binding (interaction) of in brain associated with inflammation
4) Confidence 0.32 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.65 Pain Relevance 0.31
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
CCL5 Binding (ligands) of
5) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.67 Pain Relevance 0.66
CCR3 and CCR5 expression profiles were similar to the expression profile of their corresponding RANTES ligand.
RANTES Binding (ligand) of
6) Confidence 0.28 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.62 Pain Relevance 0.09
Indeed, malaria has become one of the many inflammatory diseases in which RANTES and its receptors appear to play a role.
RANTES Binding (receptors) of associated with malaria, inflammation and disease
7) Confidence 0.28 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.34 Pain Relevance 0.41
Transfectant-expressed CCRL2 has been reported to bind CCL2 and CCL5, although this result is controversial (9).
CCL5 Binding (bind) of
8) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.12
The CHBPs described here specifically inhibit the chemokines that recruit these cell types; Evasin-1 (in rodents) and Evasin-3 prevent neutrophil accumulation, and preliminary results indicate that Evasin-4 binds the eosinophil-recruiting chemokines CCL5 and CCL11.
CCL5 Binding (binds) of in neutrophil associated with chemokine
9) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.43
, CCL5 and Scya7, is expressed as early as 3 hours post-wounding, with expression levels peaking by 12 hours.
CCL5 Binding (wounding) of
10) Confidence 0.22 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.04 Pain Relevance 0.39
The CCL5 and CCL11 binding protein was named Evasin-4.


CCL5 Binding (binding) of
11) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.17 Pain Relevance 0.03
Deconvolution of the positive pools revealed a cDNA clone that was able to mediate cross-linking to both CCL5 and CCL11 (Fig. 2 a, lanes 4 and 5), but not CXCL10 when tested in HEK293 cells.
CCL5 Binding (linking) of
12) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.15 Pain Relevance 0.04
CCL5, CCL3, and CXCL8 or the control protein, equine myoglobin, were diluted to 0.1 ?
CCL5 Binding (diluted) of
13) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0 Pain Relevance 0.04
cytokines are factors such as MCP-1 and CCL5, critical for macrophage
CCL5 Binding (factors) of in macrophage associated with cytokine
14) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 1.00 Pain Relevance 0.14
Our own analyses of tick saliva harvested during feeding also demonstrated the presence of molecules that bound to CXCL8, CCL3, and CCL5.
CCL5 Binding (bound) of in saliva
15) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.37 Pain Relevance 0.26
We analyzed the ability of saliva from Rhipicephalus sanguineus (common brown dog tick) to inhibit the binding of the I125-labeled chemokines CCL2, CCL5, and CXCL8, as well as CCL3, to their respective receptors using a scintillation proximity assay.
CCL5 Spec (analyzed) Binding (binding) of in saliva associated with chemokine
16) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.60 Pain Relevance 0.45
Migration of PBLs could be further enhanced by the addition of CXCL-10, CCL5, or CXCL-12 to the lower chamber, chemokines known to be up-regulated in RA synovial joints (Figure 6C).29 Subset analysis revealed enhanced migration of TCR?
CCL5 Binding (addition) of in synovial joints associated with chemokine and rheumatoid arthritis
17) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.16
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
CCL5 Binding (ligands) of
18) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.84 Pain Relevance 0.39
, chemokine (C-C motif) ligand 5 (CCL5 or RANTES), IL-1?
CCL5 Binding (ligand) of associated with chemokine
19) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0 Pain Relevance 0.22

General Comments

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