INT181046

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.03
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt6a)
Anatomy Link Frequency
skin 2
keratinocytes 1
Krt6a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 202 66.72 Quite High
cytokine 20 38.32 Quite Low
fibrosis 22 34.80 Quite Low
Inflammatory response 62 5.00 Very Low Very Low Very Low
chemokine 26 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 328 99.12 Very High Very High Very High
Hyperplasia 2 98.80 Very High Very High Very High
Apoptosis 4 77.96 Quite High
Acanthosis 16 71.80 Quite High
INFLAMMATION 260 66.72 Quite High
Skin Diseases 10 66.44 Quite High
Congenital Anomalies 20 65.12 Quite High
Aging 8 54.80 Quite High
Wound Healing 20 50.00 Quite Low
Targeted Disruption 34 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of expression of K6 by the front 10-12 rows of wound-edge keratinocytes were confirmed by in situ hybridization (Figure 4n).
Gene_expression (expression) of K6 in keratinocytes associated with injury
1) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.57 Pain Relevance 0
The temporal and spatial coexpression of K6 with MRP8 may highlight a relationship between them and as such reveals another advantage of cluster analysis - the ability to identify potential interactions between genes and genetic pathways within the same cluster.
Gene_expression (coexpression) of K6
2) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.46 Pain Relevance 0.03
Overexpression of K6 was already seen at the RNA level at P18, but only a weak immunoreactivity was observed in the interfollicular epidermis at this time point (unpublished data).
Gene_expression (Overexpression) of K6 in epidermis
3) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.45 Pain Relevance 0
K6, which is restricted to hair follicle keratinocytes in normal skin, was abnormally expressed in the interfollicular epidermis of adult K5-R1/R2 mice (Fig.
Gene_expression (expressed) of K6 in skin
4) Confidence 0.01 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.55 Pain Relevance 0

General Comments

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