INT181053

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.17
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 1
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 9 100.00 Very High Very High Very High
Neuropathic pain 112 99.64 Very High Very High Very High
Morphine 126 99.56 Very High Very High Very High
Hyperalgesia 71 99.32 Very High Very High Very High
Physical dependence 12 99.32 Very High Very High Very High
tolerance 1 98.44 Very High Very High Very High
addiction 115 98.28 Very High Very High Very High
Pain 117 97.68 Very High Very High Very High
opiate 45 96.72 Very High Very High Very High
Dorsal horn 54 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 167 99.80 Very High Very High Very High
Hyperalgesia 139 99.32 Very High Very High Very High
Drug Dependence 12 99.32 Very High Very High Very High
Skin Cancer 8 98.92 Very High Very High Very High
Morphine Dependence 81 98.64 Very High Very High Very High
Pain 132 97.68 Very High Very High Very High
Cancer 79 97.42 Very High Very High Very High
Targeted Disruption 100 97.12 Very High Very High Very High
Cleft Palate 1 96.92 Very High Very High Very High
Opiate Addiction 33 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, CCI treatment did not significantly alter these properties of the DRG neurons from EphB1+/- and EphB1-/- mice.
Neg (not) Regulation (alter) of EphB1 in neurons
1) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.85 Pain Relevance 0.76
All these results suggest that the transcriptional regulation of EphB1 revealed in the heatmaps for our stop cluster (Figure 5a) may reflect a functional role in the stopping or final fusion episodes of wound re-epithelialization.
Regulation (regulation) of EphB1 associated with injury
2) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.42 Pain Relevance 0
These findings indicate that the EphB1 receptor is necessary for development of neuropathic pain and physical dependence on morphine and suggest that the EphB1 receptor is a potential target for preventing, minimizing, or reversing the development of neuropathic pain and opiate dependence.



Regulation (target) of EphB1 associated with addiction, physical dependence, neuropathic pain, opiate and morphine
3) Confidence 0.27 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2605438 Disease Relevance 1.34 Pain Relevance 1.53
EphB1 receptor is a potential therapeutic target for neuropathic hyperalgesia and morphine dependence
Regulation (target) of EphB1 associated with addiction, hyperalgesia, neuropathic pain and morphine
4) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.34 Pain Relevance 1.18
They later identified EphB1 as the specific EphB receptor involved in both neuropathic pain and morphine tolerance dependence using EphB1 knockout mice [13].
Regulation (involved) of EphB receptor associated with targeted disruption, addiction, tolerance, neuropathic pain and morphine
5) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.77 Pain Relevance 1.42
As determined by quantitative real-time RT-PCR, the gene expression of ephrin B1 in lumbar (L) 4-5 DRGs was induced 1.8 fold in cancer-induced pain mice compared to normal control mice on day 15 after melanoma transplantation (p < 0.001) (Figure 1A); however, no change was observed for the Eph B1 receptor (Figure 1B).
Neg (no) Regulation (change) of Eph B1 receptor associated with pain, cancer, b1 receptor and skin cancer
6) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.45 Pain Relevance 0.88

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