INT181061

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.98
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a9) extracellular region (S100a9) plasma membrane (S100a9)
cytoskeleton (S100a9) nucleus (S100a9) cytoplasm (S100a9)
Anatomy Link Frequency
macrophages 1
leukocytes 1
neuron 1
immune system 1
neutrophils 1
S100a9 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 121 99.60 Very High Very High Very High
Inflammation 317 98.76 Very High Very High Very High
imagery 6 98.64 Very High Very High Very High
cytokine 84 90.68 High High
nociceptor 19 87.36 High High
Calcitonin gene-related peptide 22 81.40 Quite High
lidocaine 102 79.76 Quite High
Arthritis 23 78.48 Quite High
trigeminal ganglion 1 67.20 Quite High
rheumatoid arthritis 65 64.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 365 98.76 Very High Very High Very High
Disease 93 97.82 Very High Very High Very High
Infection 80 97.52 Very High Very High Very High
Injury 178 97.16 Very High Very High Very High
Death 16 96.28 Very High Very High Very High
Colon Cancer 1 94.40 High High
Targeted Disruption 66 85.88 High High
Arthritis 35 79.52 Quite High
Apoptosis 42 78.92 Quite High
Thrombosis Related Under Development 1 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the above observation that S100A8 and S100A9 proteins are located in both neutrophils and macrophages (Figure 2), we suggest that S100A8 (and S100A9) produced by neutrophils attracted more neutrophils in turn, thus forming a positive feedback in certain stages of inflammatory CorNV.
Localization (located) of S100A9 in neutrophils associated with inflammation
1) Confidence 0.74 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.36 Pain Relevance 0.15
Both are also expressed by leukocytes, and in the case of MRP14 this expression predominates and leads to cluster separation of the two genes, with MRP14 categorized as part of the early inflammatory cluster.
Localization (case) of MRP14 in leukocytes associated with inflammation
2) Confidence 0.60 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.27 Pain Relevance 0.29
Figure 1D shows double AP staining indicating colocalization of Ly6G and S100A9.
Localization (colocalization) of S100A9
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.50 Pain Relevance 0.05
Both S100A8 and S100A9 are known to be abundant cytosolic proteins in human PMN that can be secreted and exhibit potent actions in inflammatory cell recruitment [20].
Localization (secreted) of S100A9 associated with inflammation
4) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.75 Pain Relevance 0.64
S100A8 and S100A9 proteins are secreted in an energy-dependent fashion by phagocytes during inflammatory processes.
Localization (secreted) of S100A9 in phagocytes associated with inflammation
5) Confidence 0.40 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.50 Pain Relevance 0.12
Considering the above observation that S100A8 and S100A9 proteins are located in both neutrophils and macrophages (Figure 2), we suggest that S100A8 (and S100A9) produced by neutrophils attracted more neutrophils in turn, thus forming a positive feedback in certain stages of inflammatory CorNV.
Localization (located) of S100A9 in macrophages associated with inflammation
6) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.36 Pain Relevance 0.15
Approximately, 5-fold more P14 cells were recruited into the CNS of Armstrong versus clone 13 infected mice at day 8 p.i.
Localization (recruited) of P14 associated with central nervous system
7) Confidence 0.25 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0 Pain Relevance 0.23
The predominant role of the innate immune system in systemic onset disease is also underscored by the high expression and serum concentrations of the calcium-binding proteins S100A8, S100A9, and S100A12, which are specifically secreted during activation of neutrophilic granulocytes and monocytes47).
Localization (secreted) of S100A9 in immune system associated with disease
8) Confidence 0.21 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.08 Pain Relevance 0.24
In ret mutants, no neuron loss is reported from P14 DRG.
Localization (reported) of P14 in neuron
9) Confidence 0.15 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.16 Pain Relevance 0.30

General Comments

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