INT181103

Context Info Confidence 0.10 First Reported 2004 Last Reported 2004 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.61 Pain Relevance 0

kinase activity (Chka) cytoplasm (Chka)

Chka (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 6 5.00 Inflammation 3 5.00

Disease Link Frequency Relevance Heat Carcinoma 48 99.84 Cancer 162 99.52 Breast Cancer 114 97.78 Necrosis 3 97.68 Adhesions 15 83.04 Metastasis 9 81.40 Recurrence 12 44.24 Disease Progression 3 7.92 Disease 54 5.00 Bacterial Respiratory Disease 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, anti-CK immunohistochemistry performed on primary tumor specimens from patients demonstrated the large heterogeneity in CK expression on carcinoma cells (data not shown).

Regulation (heterogeneity) of Gene_expression (expression) of CK associated with cancer and carcinoma

1) Confidence 0.10 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.81 Pain Relevance 0

Major CK alterations observed in breast cancer could be reflected by the reduced or increased expression of individual CK, and by partial loss of the normal regulation of CK expression [45].

Spec (partial) Regulation (regulation) of Gene_expression (expression) of CK associated with breast cancer

2) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.75 Pain Relevance 0

Modulation of CK expression along with tumor progression has also been reported [42-44].

Regulation (Modulation) of Gene_expression (expression) of CK associated with cancer

3) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 1.06 Pain Relevance 0

General Comments

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