INT181104

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.53
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Epcam)
Anatomy Link Frequency
blood 1
lung 1
Epcam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 79.92 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 249 99.92 Very High Very High Very High
Metastasis 19 99.84 Very High Very High Very High
Carcinoma 52 99.80 Very High Very High Very High
Colon Cancer 4 98.52 Very High Very High Very High
Necrosis 3 98.16 Very High Very High Very High
Adhesions 18 97.88 Very High Very High Very High
Lung Cancer 1 97.76 Very High Very High Very High
Death 6 95.92 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 14 91.68 High High
Breast Cancer 132 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several authors reported the heterogeneous expression of EpCAM in mammary carcinomas [15,19]; downregulation of EpCAM was reported for disseminated tumor cells in bone marrow and CTCs in peripheral blood [15,19,48].
Negative_regulation (downregulation) of EpCAM in blood associated with cancer and carcinoma
1) Confidence 0.55 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575542 Disease Relevance 0.50 Pain Relevance 0
EpCAM may be downregulated on metastatic tumor cells because loss of cell-cell adhesion is a prerequisite for tumor cell dissemination [38,39].
Negative_regulation (downregulated) of EpCAM associated with cancer, adhesions and metastasis
2) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 1.24 Pain Relevance 0
The sole in vitro mechanism described that can account for EpCAM downregulation is a transcriptional effect induced by tumor necrosis factor alpha and mediated by nuclear factor kappaB [41].
Negative_regulation (downregulation) of EpCAM associated with necrosis and cancer
3) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 1.08 Pain Relevance 0
We agree that Ficoll processing might eliminate cell clusters or aggregates, leading to the preferential loss of EpCAM-expressing cells.
Negative_regulation (loss) of EpCAM
4) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.67 Pain Relevance 0
VB4-845 studies have previously shown significant growth inhibition of EpCAM-positive, human tumor xenografts of colorectal cancer, small cell lung cancer, and SCCHN in mice (Di Paolo et al 2003).
Negative_regulation (inhibition) of EpCAM in lung associated with lung cancer, cancer and colon cancer
5) Confidence 0.11 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761172 Disease Relevance 1.04 Pain Relevance 0.04

General Comments

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