INT181128

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 7.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) signal transduction (Raf1) plasma membrane (Raf1)
cytoskeleton organization (Raf1) kinase activity (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
T cell 1
Raf1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 16 72.48 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 248 99.84 Very High Very High Very High
Targeted Disruption 72 99.68 Very High Very High Very High
Cancer 224 99.30 Very High Very High Very High
Immunization 104 98.70 Very High Very High Very High
Adenoma 56 98.48 Very High Very High Very High
Lung Cancer 32 88.32 High High
Skin Cancer 24 66.00 Quite High
Metastasis 8 65.52 Quite High
Colon Cancer 8 51.08 Quite High
Autoimmune Disease 8 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, immunization of mice with the Salmonella enterica serovar Typhimurium aroA strain SL7207 secreting C-Raf resulted in the induction of a humoral immune response, manifested by the presence of Raf-specific antibodies in some of the vaccinated mice.
Localization (secreting) of C-Raf associated with immunization and sprains and strains
1) Confidence 0.69 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.74 Pain Relevance 0.04
In addition, the immunization of wild-type C57BL/6 or tumor bearing transgenic mice with this C-Raf secreting Salmonella strain provoked specific C-Raf antibody and T cell responses.
Localization (secreting) of C-Raf in T cell associated with targeted disruption, cancer, immunization and sprains and strains
2) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 1.44 Pain Relevance 0
The S. typhimurium SL7207/pMOhly-Raf strain efficiently expressed and secreted the hybrid C-Raf protein, as shown by immunoblotting with polyclonal antibodies raised against C-Raf (Fig. 2).
Localization (secreted) of C-Raf associated with sprains and strains
3) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.49 Pain Relevance 0
Taken together we have demonstrated that the C-Raf antigen can be successfully expressed and secreted by the attenuated Salmonella enterica serovar Typhimurium aroA SL7207 strain via the E. coli hemolysin secretion system.
Localization (secreted) of C-Raf associated with sprains and strains
4) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 1.43 Pain Relevance 0
In our case, the whole C-Raf antigen fused to the C-terminal secretion signal of hemolysin was efficiently expressed and secreted by an attenuated Salmonella enterica serovar Typhimurium aroA strain.
Localization (secreted) of C-Raf associated with sprains and strains
5) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.72 Pain Relevance 0
The construction of the attenuated Salmonella enterica serovar Typhimurium aroA strain SL7207 secreting the C-Raf antigen was achieved by cloning the human craf cDNA from pUC13-c-raf-1 [12] into the vector plasmid pMOhly1 [13] as described in materials and methods.
Localization (secreting) of C-Raf associated with sprains and strains
6) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.32 Pain Relevance 0
The amount of secreted C-Raf was 2–3 ?
Localization (secreted) of C-Raf
7) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.50 Pain Relevance 0
The combination of the C-Raf antigen, hemolysin secretion system and Salmonella enterica serovar Typhimurium could form the basis for a new generation of live bacterial vaccines for the treatment of Raf dependent human malignancies.



Localization (secretion) of C-Raf
8) Confidence 0.60 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC549196 Disease Relevance 1.43 Pain Relevance 0

General Comments

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