INT181133

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.65
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 8
lymphocytes 2
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 5 95.44 Very High Very High Very High
cytokine 66 74.36 Quite High
Inflammation 61 65.44 Quite High
Neuropeptide 4 50.00 Quite Low
fibrosis 3 48.16 Quite Low
chemokine 11 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 25 100.00 Very High Very High Very High
Hypersensitivity Pneumonitis 70 96.00 Very High Very High Very High
Infection 108 92.80 High High
Asthma 41 90.04 High High
Sprains And Strains 38 89.40 High High
Targeted Disruption 14 87.44 High High
Immunization 35 86.64 High High
Apoptosis 21 86.52 High High
Cancer 75 80.48 Quite High
INFLAMMATION 60 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Negative_regulation (minimal) of Gene_expression (Expression) of CD8 in T cells
1) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Hence, our results are in accordance with the earlier findings by Neumann-Andersen et al. showing the expression of MC-1R on natural killer cells and cytotoxic CD8+ T cells whereas only 1% of CD4+ T cells could be stained for MC-1R [57].
Negative_regulation (showing) of Gene_expression (expression) of CD8 in T cells
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0 Pain Relevance 0
Therefore, CD8:CD4 T cell ratio was reduced in BALF of Fc?
Negative_regulation (reduced) of Gene_expression (ratio) of CD8 in T cell
3) Confidence 0.12 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.62 Pain Relevance 0.03
Immuno-magnetic depletion of CD4+ and CD8+ lymphocytes
Negative_regulation (depletion) of Gene_expression (lymphocytes) of CD8 in lymphocytes
4) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.05 Pain Relevance 0
RAE and CsA groups treated with OVA resulted in further significant reductions in CD4+/CD8?
Negative_regulation (reductions) of Gene_expression (/) of CD8
5) Confidence 0.07 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.06
In addition, C57BL/6 mice immunized with Salmonella enterica serovar Typhimurium SL7207/pMOhly-Raf developed a Raf-specific CD8+ T-cell response.
Negative_regulation (developed) of Gene_expression (response) of CD8 in T-cell
6) Confidence 0.04 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.68 Pain Relevance 0.08
Blockade of activated T CD8 death increased IFN-?
Negative_regulation (Blockade) of Gene_expression (death) of CD8 associated with death
7) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.08 Pain Relevance 0.07

General Comments

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