INT18114

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Context Info
Confidence 0.66
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 57.85
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
plasma 3
lymph nodes 2
mandible 1
stroma 1
Epithelial cells 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 99.52 Very High Very High Very High
antagonist 2 99.24 Very High Very High Very High
Pain 29 96.20 Very High Very High Very High
corticosteroid 1 94.84 High High
GABAergic 28 92.72 High High
alcohol 16 92.60 High High
metalloproteinase 28 90.12 High High
opioid receptor 2 87.76 High High
Potency 1 84.08 Quite High
Hippocampus 52 83.80 Quite High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 4003 100.00 Very High Very High Very High
Cancer 1573 100.00 Very High Very High Very High
Epstein-barr Virus 1086 100.00 Very High Very High Very High
Metastasis 358 99.84 Very High Very High Very High
Disease 586 99.32 Very High Very High Very High
Genetic Predisposition To Disease 56 99.28 Very High Very High Very High
Recurrence 98 99.20 Very High Very High Very High
Neurodegenerative Disease 109 99.08 Very High Very High Very High
Malignant Neoplastic Disease 209 98.48 Very High Very High Very High
Otitis Media 15 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
technologies and microdissection tools, comprehensive expression profiling of NPC
Gene_expression (expression) of NPC associated with nasopharynx cancer
1) Confidence 0.66 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.50 Pain Relevance 0
NPC: HLA-2, HLA-B17, and HLA-Bw26 double the risk of the disease, and genomic and cytogenetic
Gene_expression (double) of NPC associated with nasopharynx cancer and disease
2) Confidence 0.66 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.57 Pain Relevance 0.05
The positive gradual expression of estrogen and progestogen receptors in NPC was well correlated with distant metastasis.
Gene_expression (expression) of NPC associated with nasopharynx cancer and metastasis
3) Confidence 0.58 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.56 Pain Relevance 0
Measuring the expression of latent EBV genes in NPC and normal nasopharyngeal tissue samples, it was shown that deregulation of key proteins involving in apoptosis (bcl-2 related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1 and NIN) and metastasis (matrix metalloproteinase 1) were closely correlated with the levels of EBV gene expression in NPC [77].
Gene_expression (expression) of NPC associated with nasopharynx cancer, metalloproteinase, epstein-barr virus, apoptosis and metastasis
4) Confidence 0.58 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.93 Pain Relevance 0.05
In general, NPC is thought to be the result of both
Gene_expression (result) of NPC associated with nasopharynx cancer
5) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.73 Pain Relevance 0
identified in neoplastic cells of virtually all cases of NPC, and the clonal
Gene_expression (cases) of NPC associated with nasopharynx cancer
6) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.83 Pain Relevance 0.03
Nitrosamines are the effective carcinogens for NPC and are
Gene_expression (carcinogens) of NPC associated with nasopharynx cancer
7) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.81 Pain Relevance 0
NPC tumorigenesis may be through its cytotoxic T cell recognition and host immune
Gene_expression (tumorigenesis) of NPC in cytotoxic T cell associated with nasopharynx cancer
8) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.93 Pain Relevance 0
profiling studies of NPC, these techniques for “reverse inference” of DNA
Gene_expression (studies) of NPC associated with nasopharynx cancer
9) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.48 Pain Relevance 0
NPC after radiation and chemotherapy is a radical surgery of the lymph nodes of
Gene_expression (surgery) of NPC in lymph nodes associated with nasopharynx cancer
10) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.95 Pain Relevance 0
In general, NPC is thought to be the result of both
Gene_expression (thought) of NPC associated with nasopharynx cancer
11) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.71 Pain Relevance 0
profiling of NPC is now starting to take the center stage.
Gene_expression (profiling) of NPC associated with nasopharynx cancer
12) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.35 Pain Relevance 0
While substantial amount of information on the genomic alteration of NPC have been
Gene_expression (alteration) of NPC associated with nasopharynx cancer
13) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.84 Pain Relevance 0
Most of the linkage studies on NPC performed so far have used
Gene_expression (studies) of NPC associated with nasopharynx cancer
14) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.52 Pain Relevance 0
factors contribute to NPC include the consumption of foods high in salt,
Gene_expression (contribute) of NPC associated with nasopharynx cancer
15) Confidence 0.58 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.83 Pain Relevance 0.04
It has been reported that average expression of Tiam1 in NPC tissue was higher than in normal nasopharyngeal tissue.
Gene_expression (tissue) of NPC associated with nasopharynx cancer
16) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.34 Pain Relevance 0
Three were initially misdiagnosed as having NPC according to MRI findings, and all underwent nasopharyngeal biopsy to exclude malignancy. 7/7 (100%) patients received systemic corticosteroid treatment; 7/7 (100%) showed initial rapid resolution of clinical symptoms or radiographical findings; 3/7 (42.9%) had resolution of all signs and symptoms; 3/7 (42.9%) still have limited residual symptoms; and 1/7 (14.3%) suffered recurrence 3 years after remission.
Gene_expression (having) of NPC associated with malignant neoplastic disease, corticosteroid, nasopharynx cancer and recurrence
17) Confidence 0.53 Published 2010 Journal Br J Radiol Section Abstract Doc Link 19470567 Disease Relevance 1.05 Pain Relevance 0.30
preamplification technology, comprehensive expression profiling of NPC is now
Gene_expression (expression) of NPC associated with nasopharynx cancer
18) Confidence 0.51 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.82 Pain Relevance 0
The

detection of NPC is based on the clinical history and the physical examination,

Gene_expression (detection) of NPC associated with nasopharynx cancer
19) Confidence 0.51 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.48 Pain Relevance 0.04
for NPC have also been detected with polymorphism in toll-like receptor 1, 6, 10,
Gene_expression (detected) of NPC associated with nasopharynx cancer
20) Confidence 0.51 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.91 Pain Relevance 0

General Comments

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