INT181177

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 5
Total Number 29
Disease Relevance 24.96
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD)
cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)
Anatomy Link Frequency
skin 3
epithelium 1
bowel 1
basal layer 1
CYLD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 157 99.28 Very High Very High Very High
Inflammatory mediators 26 97.80 Very High Very High Very High
cytokine 62 95.76 Very High Very High Very High
cINOD 30 91.48 High High
headache 6 53.04 Quite High
psoriasis 25 29.76 Quite Low
Inflammatory response 4 26.48 Quite Low
colic 11 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholesteatoma 1500 100.00 Very High Very High Very High
Skin Cancer 83 100.00 Very High Very High Very High
Short Bowel Syndrome 38 100.00 Very High Very High Very High
Sick Building Syndrome 10 100.00 Very High Very High Very High
Crohn's Disease 109 99.76 Very High Very High Very High
Rheumatoid Arthritis 601 99.70 Very High Very High Very High
Cancer 164 99.66 Very High Very High Very High
INFLAMMATION 209 99.28 Very High Very High Very High
Apoptosis 301 98.60 Very High Very High Very High
Middle Ear Cholesteatoma 50 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CYLD and NF-?
Gene_expression (Expression) of CYLD
1) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Title Doc Link PMC2858283 Disease Relevance 1.16 Pain Relevance 0.05
B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (P < .05).
Gene_expression (expression) of CYLD in skin associated with cholesteatoma and rheumatoid arthritis
2) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2858283 Disease Relevance 1.23 Pain Relevance 0.04
Therefore, investigation of CYLD expression may be a key step to understanding the cellular survival or hyperplasia in cholesteatoma epithelium.
Gene_expression (expression) of CYLD in epithelium associated with cholesteatoma and hyperplasia
3) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.92 Pain Relevance 0
We then compared the expression levels of CYLD and activated NF-?
Gene_expression (expression) of CYLD
4) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.69 Pain Relevance 0
CYLD is expressed in multiple tissues, but its precise biological function remains unclear.
Gene_expression (expressed) of CYLD
5) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.84 Pain Relevance 0.09
We conducted immunohistochemistry to examine the expression of CYLD and NF-?
Spec (examine) Gene_expression (expression) of CYLD
6) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2858283 Disease Relevance 1.17 Pain Relevance 0.05
B (number of cells with nuclear staining/total number of cells counted) and CYLD expression (number of positively stained cells/total number of cells counted) were obtained and expressed as percentages.
Gene_expression (expression) of CYLD
7) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.18 Pain Relevance 0
In addition, the present findings suggested that downregulation of CYLD expression, which is highly expressed in normal skin, may be involved in the pathogenesis of human cholesteatoma.
Gene_expression (expression) of CYLD in skin associated with cholesteatoma
8) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.33 Pain Relevance 0
As noted above, a series of reports have shown that CYLD blocks signal transmission through the classical or alternative NF-?
Neg (blocks) Gene_expression (blocks) of CYLD
9) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.74 Pain Relevance 0.09
Furthermore, a significant inverse correlation was detected between CYLD and activated NF-?
Gene_expression (detected) of CYLD
10) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2858283 Disease Relevance 1.22 Pain Relevance 0.04
B signaling of cholesteatoma, CYLD and NF-?
Gene_expression (signaling) of CYLD associated with cholesteatoma
11) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.18 Pain Relevance 0
We also examined the relationships between CYLD/NF-?
Gene_expression (/) of CYLD
12) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.01 Pain Relevance 0.05
The results of the present study indicated that the level of CYLD expression was significantly downregulated in cholesteatoma in comparison with normal RA skin.
Gene_expression (expression) of CYLD in skin associated with rheumatoid arthritis and cholesteatoma
13) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.91 Pain Relevance 0
Specifically, we were interested in whether CYLD expression is altered in cholesteatoma and whether CYLD expression level affects the activity of NF-?
Spec (whether) Gene_expression (expression) of CYLD associated with cholesteatoma
14) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.91 Pain Relevance 0
We found that CYLD expression was lower and activated NF-?
Gene_expression (expression) of CYLD
15) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.85 Pain Relevance 0
Specifically, we were interested in whether CYLD expression is altered in cholesteatoma and whether CYLD expression level affects the activity of NF-?
Spec (whether) Gene_expression (expression) of CYLD associated with cholesteatoma
16) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.92 Pain Relevance 0
We also examined the relationship between CYLD expression and NF-?
Gene_expression (expression) of CYLD
17) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.21 Pain Relevance 0
The present study was performed to examine the possible role of CYLD expression in the pathogenesis of cholesteatoma.
Gene_expression (expression) of CYLD associated with cholesteatoma
18) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.91 Pain Relevance 0
In the present study, the cytoplasmic and perinuclear expression levels of CYLD suggest that CYLD may play a role in the deubiquitination of BCl-3 and/or TRAF in NF-?
Spec (suggest) Gene_expression (suggest) of CYLD
19) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.29 Pain Relevance 0
The tumor suppressor gene CYLD, which was recently identified as the cylindromatosis gene, has a deubiquitinating enzyme (DUB) activity and inhibits activation of the transcription factor NF-?
Gene_expression (identified) of CYLD associated with cancer and skin cancer
20) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.38 Pain Relevance 0.14

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