INT181179

Context Info Confidence 0.43 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 7 Disease Relevance 7.06 Pain Relevance 0.39

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD) cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)

CYLD (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory mediators 5 97.80 cytokine 19 95.76 Inflammation 27 94.40 headache 3 87.84 Catecholamine 1 23.00 cINOD 9 5.00 tolerance 7 5.00 psoriasis 4 5.00 addiction 2 5.00 carpal tunnel syndrome 1 5.00

Disease Link Frequency Relevance Heat Short Bowel Syndrome 38 100.00 Sick Building Syndrome 19 100.00 Skin Cancer 12 100.00 Cancer 52 99.66 Stress 11 98.04 INFLAMMATION 37 97.40 Cholesteatoma 240 97.32 Rheumatoid Arthritis 96 96.44 Pruritus 2 94.16 Hypersensitivity 10 92.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At this point, CYLD binds to NF-?

CYLD Binding (binds) of

1) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.48 Pain Relevance 0.03

B activation accompanied by loss of CYLD may be an important step in the development and/or progression of cholesteatoma.

CYLD Binding (loss) of associated with cholesteatoma

2) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.05 Pain Relevance 0.06

To find the association between CYLD and NF-?

CYLD Binding (association) of

3) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.09 Pain Relevance 0

Excessive work stress or dissatisfaction, poor interpersonal relationships and poor communication are often seen to be associated with SBS. 6.

SBS Binding (associated) of associated with stress and sick building syndrome

4) Confidence 0.32 Published 2008 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2796751 Disease Relevance 0.55 Pain Relevance 0

The tumor suppressor gene CYLD, which was recently identified as the cylindromatosis gene, has a deubiquitinating enzyme (DUB) activity and inhibits activation of the transcription factor NF-?

CYLD Binding (inhibits) of associated with cancer and skin cancer

5) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.42 Pain Relevance 0.14

Complications of SBS

SBS Binding (Complications) of associated with short bowel syndrome

6) Confidence 0.14 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 1.04 Pain Relevance 0.07

On the basis of a WHO report,(367) Mølhave(368) has suggested a definition for SBS.

SBS Binding (definition) of associated with sick building syndrome

7) Confidence 0.08 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855181 Disease Relevance 1.43 Pain Relevance 0.09

General Comments

This test has worked.