INT181194

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 31
Total Number 34
Disease Relevance 21.27
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
liver 4
hepatocytes 2
Section 2 2
adipose tissue 2
lung 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 492 100.00 Very High Very High Very High
COX2 83 100.00 Very High Very High Very High
Inflammation 560 99.98 Very High Very High Very High
Osteoarthritis 203 98.32 Very High Very High Very High
Inflammatory mediators 23 97.80 Very High Very High Very High
cytokine 65 92.96 High High
ischemia 30 92.16 High High
Inflammatory response 56 91.44 High High
addiction 6 90.60 High High
Arthritis 16 70.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 672 99.98 Very High Very High Very High
Targeted Disruption 48 99.92 Very High Very High Very High
Obesity 900 99.86 Very High Very High Very High
Cancer 853 99.76 Very High Very High Very High
Insulin Resistance 55 99.72 Very High Very High Very High
Polyps 20 99.60 Very High Very High Very High
Shock 1 98.36 Very High Very High Very High
Osteoarthritis 206 98.32 Very High Very High Very High
Stress 43 95.12 Very High Very High Very High
Pathologic Neovascularization 22 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, this effect does not depend on PPAR agonism, but it is related to
Neg (not) Regulation (depend) of Gene_expression (agonism) of PPAR
1) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.66 Pain Relevance 0.03
, based on the characteristic nucleotide sequence [32], [33], on known similarities in tissue expression between ERR and PPAR?
Regulation (similarities) of Gene_expression (expression) of PPAR
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
The PPAR-independent anti-inflammatory effects of PPAR agonists
Regulation (effects) of Gene_expression (agonists) of PPAR associated with inflammation and agonist
3) Confidence 0.43 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.99 Pain Relevance 0.62
confirm the results obtained on PPAR?
Regulation (results) of Gene_expression (obtained) of PPAR
4) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.23 Pain Relevance 0.15
Furthermore, different PPAR agonists can yield markedly different patterns of gene modulation which will result in complex and largely unknown differences in effects on metabolic pathways.47

TZDs and heart failure

Regulation (different) of Gene_expression (agonists) of PPAR in heart associated with agonist and myocardial infarction
5) Confidence 0.40 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.85 Pain Relevance 0.05
Albeit the lower expression of PPAR?
Regulation (Albeit) of Gene_expression (expression) of PPAR
6) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.17 Pain Relevance 0.33
Anti-inflammatory effects of PPAR ligands, in
Regulation (effects) of Gene_expression (ligands) of PPAR associated with inflammation
7) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.90 Pain Relevance 0.51
response in the absence of PPAR?
Regulation (response) of Neg (absence) Gene_expression (absence) of PPAR
8) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.41 Pain Relevance 0.44
Targeted deletion of PPAR?
Regulation (Targeted) of Gene_expression (deletion) of PPAR
9) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.27 Pain Relevance 0.12
agonists has clearly shown that this glitazone does not significantly regulate any of the PPAR?
Neg (not) Regulation (regulate) of Gene_expression (any) of PPAR associated with agonist
10) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.12 Pain Relevance 0.36
These investigations reveal that SULT2A1 represents a target for lipid signaling in human hepatocytes and suggest that rodent models do not capture the significance of PPAR?
Neg (not) Regulation (capture) of Gene_expression (significance) of PPAR in hepatocytes
11) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.08
target adiponectin, should be up-regulated by expressing PPAR?
Regulation (regulated) of Gene_expression (expressing) of PPAR
12) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0
For example, adenoviral delivery of PPAR?
Regulation (adenoviral) of Gene_expression (delivery) of PPAR
13) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.39 Pain Relevance 0
and its ligands in inhibiting or promoting angiogenesis is likely context dependent (Section 2.7 and Table 3) [30, 332]; thus, the use of PPAR?
Regulation (dependent) of Gene_expression (use) of PPAR in Section 2
14) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.50 Pain Relevance 0.23
effects, and there is no correlation between the expression levels of PPAR?
Regulation (correlation) of Gene_expression (expression) of PPAR
15) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.43 Pain Relevance 0.19
However, little is known about the expression and regulation of PPAR?
Regulation (regulation) of Gene_expression (expression) of PPAR
16) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.73 Pain Relevance 0.38
To elucidate the mechanism responsible for the changes in amounts of PPAR?
Regulation (changes) of Gene_expression (amounts) of PPAR
17) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.29 Pain Relevance 0.15
2 in mice resulted in a lipogenic liver phenotype and induction of several PPAR?
Regulation (resulted) of Gene_expression (phenotype) of PPAR in liver
18) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.36 Pain Relevance 0
For determination of the effects of liver overexpression of murine PPAR?
Regulation (effects) of Gene_expression (overexpression) of PPAR in liver
19) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0
Based on the large comprehensive amount of data gained in this study it seems to be promising to further develop experimental protocols that employ COX2/PPAR biomodulation.
Regulation (employ) of Gene_expression (biomodulation) of PPAR associated with cox2
20) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.73 Pain Relevance 0.38

General Comments

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