INT18121

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 2.40
Pain Relevance 9.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 3
liver 2
neurons 2
nucleus 2
sympathetic 1
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 48 100.00 Very High Very High Very High
Catechol-O-methyltransferase 11 100.00 Very High Very High Very High
local anesthetic 7 100.00 Very High Very High Very High
beta blocker 6 99.72 Very High Very High Very High
narcan 3 99.72 Very High Very High Very High
fluoxetine 53 99.52 Very High Very High Very High
Dopamine 73 98.88 Very High Very High Very High
Morphine 3 98.08 Very High Very High Very High
lidocaine 2 97.76 Very High Very High Very High
withdrawal 5 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 1 99.56 Very High Very High Very High
Diabetes Mellitus 25 98.96 Very High Very High Very High
Apoptosis 13 98.76 Very High Very High Very High
Depression 43 95.56 Very High Very High Very High
Serotonin Syndrome 5 95.36 Very High Very High Very High
Anxiety Disorder 5 94.96 High High
Migraine Disorders 4 94.28 High High
Mydriatic 1 93.40 High High
Disease 88 88.56 High High
Hypertension 3 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It occurs mainly as a result of the interaction of MAO inhibitor with tyramine in foodstuffs.
MAO Binding (interaction) of
1) Confidence 0.48 Published 1990 Journal Acta Physiol Hung Section Abstract Doc Link 2127505 Disease Relevance 0 Pain Relevance 0.04
Interaction of psychotropic drugs with monoamine oxidase in rat brain.
monoamine oxidase Binding (Interaction) of in brain associated with monoamine
2) Confidence 0.48 Published 2001 Journal J. Pharm. Pharmacol. Section Title Doc Link 11518022 Disease Relevance 0 Pain Relevance 0.39
Preincubation of liver membranes with the MAO inhibitor clorgyline (10(-7) M) abolished the binding of [3H]Ro 41-1049 (N-(2-aminoethyl)-5-(m-fluorophenyl)-4-thiazole carboxamide) to MAO-A, but it did not alter the binding of [3H]Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide) to MAO-B or that of [3H]2-BFI to I2-sites.
MAO Binding (binding) of in liver
3) Confidence 0.48 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9228188 Disease Relevance 0 Pain Relevance 0.10
Since the soy isoflavone supplements used in the research trial consisted of 63% (178 mg aglycone units/g) genistein, 28% (79.1 mg aglycone units/g) daidzein and 9% (24.6 aglycone units/g) glycitein (percentages based on aglycone units), the daidzein in the supplement may have interacted with monoamine oxidase.
monoamine oxidase Binding (interacted) of associated with monoamine
4) Confidence 0.38 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1181821 Disease Relevance 0.32 Pain Relevance 0.36
These results suggest that the inhibition of MAO activities by local anesthetics depends on both electrostatic and hydrophobic interactions between these drugs and enzyme-associated phospholipids or the hydrophobic regions of proteins.
MAO Binding (interactions) of associated with local anesthetic
5) Confidence 0.37 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6285048 Disease Relevance 0 Pain Relevance 0.73
Preincubation of liver membranes with the MAO inhibitor clorgyline (10(-7) M) abolished the binding of [3H]Ro 41-1049 (N-(2-aminoethyl)-5-(m-fluorophenyl)-4-thiazole carboxamide) to MAO-A, but it did not alter the binding of [3H]Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide) to MAO-B or that of [3H]2-BFI to I2-sites.
MAO Binding (binding) of in liver
6) Confidence 0.37 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9228188 Disease Relevance 0 Pain Relevance 0.09
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.
MAO-A Binding (binding) of in brain associated with narcan, noradrenaline, withdrawal and morphine
7) Confidence 0.36 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16061219 Disease Relevance 0 Pain Relevance 0.41
Interactions of a non-selective monoamine oxidase inhibitor, phenelzine, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake.
monoamine oxidase Binding (Interactions) of associated with dopamine, noradrenaline and monoamine
8) Confidence 0.36 Published 1984 Journal J Psychiatr Res Section Title Doc Link 6747915 Disease Relevance 0 Pain Relevance 0.68
Many imidazoline ligands have been shown to bind to the active sites of several amine oxidases, and endogenous ligands such as agmatine and tryptamine are amine oxidase substrates.
amine oxidase Binding (bind) of
9) Confidence 0.35 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028605 Disease Relevance 0 Pain Relevance 0.11
Interactions of non-selective monoamine oxidase inhibitors, tranylcypromine and nialamide, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake.
monoamine oxidase Binding (Interactions) of associated with dopamine, noradrenaline and monoamine
10) Confidence 0.33 Published 1984 Journal J Psychiatr Res Section Title Doc Link 6235366 Disease Relevance 0.06 Pain Relevance 0.45
Acute MAO inhibition with clorgyline produces distinct physiological effects in the CNS, but not in peripheral sympathetic nerves.
MAO Neg (inhibition) Binding (inhibition) of in sympathetic
11) Confidence 0.32 Published 1990 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 1965197 Disease Relevance 0 Pain Relevance 0.19
Tyramine, an indirectly acting sympathomimetic found in aged cheeses and cured meats, is metabolized by MAO in the gastrointestinal system.
MAO Binding (metabolized) of in gastrointestinal system
12) Confidence 0.32 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 0.54 Pain Relevance 0.40
Therefore, fluoxetine may enter the cell and interact with monoamine oxidase (MAO), enzyme present in both neurons and glia and that metabolises the classical monoamine neurotransmitters [43].
monoamine oxidase Binding (interact) of in neurons associated with neurotransmitter, monoamine and fluoxetine
13) Confidence 0.30 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.82
Therefore, fluoxetine may enter the cell and interact with monoamine oxidase (MAO), enzyme present in both neurons and glia and that metabolises the classical monoamine neurotransmitters [43].
MAO Binding (interact) of in neurons associated with neurotransmitter, monoamine and fluoxetine
14) Confidence 0.30 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.83
Since mitochondria-associated MAO and the cytosolic COMT do not enter the nucleus, it remains to be determined how and by which mechanism intranuclear actions of catecholamines are terminated.
MAO Neg (not) Binding (enter) of in nucleus associated with catechol-o-methyltransferase and catecholamine
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.10 Pain Relevance 0.67
Since mitochondria-associated MAO and the cytosolic COMT do not enter the nucleus, it remains to be determined how and by which mechanism intranuclear actions of catecholamines are terminated.
MAO Binding (associated) of in nucleus associated with catechol-o-methyltransferase and catecholamine
16) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.10 Pain Relevance 0.66
The results show that the combination of MAO-I's and beta-blockers can be administered safely, and can lead to the reduction in the side effects with either drug alone.
MAO-I Binding (combination) of associated with beta blocker
17) Confidence 0.12 Published 1995 Journal Biol. Psychiatry Section Abstract Doc Link 8573662 Disease Relevance 0.75 Pain Relevance 0.74
Although TAs also used to increase if their metabolism by monoamine oxidase enzyme were impeded, simultaneous DA accumulation in the effluent was not detected.
monoamine oxidase enzyme Binding (metabolism) of associated with dopamine and monoamine
18) Confidence 0.10 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0.05 Pain Relevance 0.66
Other investigators reported the association of serum monoamine oxidase level and retinopathy in diabetes mellitus [20].
serum monoamine oxidase Binding (association) of associated with diabetes mellitus, ocular toxicity (including many sub-types) and monoamine
19) Confidence 0.07 Published 2008 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2709476 Disease Relevance 0.39 Pain Relevance 0.05
When comparing specific response to nonspecific response, we found significant negative associations in three SNPs in the HTR2A gene (P=0.001-0.03) and two SNPs in the MAOA gene (P=0.03-0.05).
MAOA Neg (negative) Binding (associations) of
20) Confidence 0.04 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15052272 Disease Relevance 0 Pain Relevance 0.36

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