INT181240

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2005
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ZBTB32) nuclear chromosome (ZBTB32) nucleus (ZBTB32)
intracellular (ZBTB32) DNA binding (ZBTB32)
ZBTB32 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 144 98.80 Very High Very High Very High
Potency 12 96.88 Very High Very High Very High
opioid receptor 30 82.04 Quite High
addiction 18 80.72 Quite High
tolerance 18 80.16 Quite High
Opioid 24 71.44 Quite High
Kappa opioid receptor 144 36.40 Quite Low
antagonist 54 17.44 Low Low
mu opioid receptor 102 7.84 Low Low
Dynorphin 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 12 15.20 Low Low
Myocardial Infarction 6 12.60 Low Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rog-A shows no desensitization after a brief spiradoline pretreatment, while the same treatment reduces the potency of spiradoline at Rog-?
Neg (no) Regulation (desensitization) of Rog associated with potency
1) Confidence 0.29 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.31
Longer spiradoline pretreatment induces normal AC superactivation at Rog-A, but does not affect the AC response in Rog-?
Neg (not) Regulation (affect) of Rog
2) Confidence 0.26 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.28
Spiradoline pretreatment strongly reduced the response of Rog-?
Regulation (response) of Rog
3) Confidence 0.26 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.03
Comparison of the regulation and signaling of Rog, Rog-A, Rog-?
Regulation (regulation) of Rog
4) Confidence 0.18 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.25
Comparison of the regulation and signaling of Rog, Rog-A, Rog-?
Regulation (regulation) of Rog
5) Confidence 0.18 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.25
Comparison of the regulation and signaling of Rog, Rog-A, Rog-?
Regulation (regulation) of Rog
6) Confidence 0.18 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.25

General Comments

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