INT181246

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 1.37
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ZBTB32) nuclear chromosome (ZBTB32) nucleus (ZBTB32)
intracellular (ZBTB32) DNA binding (ZBTB32)
ZBTB32 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 288 100.00 Very High Very High Very High
Opioid 48 99.68 Very High Very High Very High
mu opioid receptor 204 98.08 Very High Very High Very High
Potency 24 96.44 Very High Very High Very High
depression 249 95.12 Very High Very High Very High
Kappa opioid receptor 288 88.84 High High
Dynorphin 60 77.64 Quite High
opioid receptor 60 73.88 Quite High
addiction 36 72.56 Quite High
tolerance 36 72.00 Quite High
Disease Link Frequency Relevance Heat
Depression 315 95.12 Very High Very High Very High
Disease 12 91.92 High High
Stress 6 83.52 Quite High
Targeted Disruption 24 81.92 Quite High
Death 9 52.44 Quite High
Suicidal Behaviour 12 50.92 Quite High
Pain 12 44.40 Quite Low
Sleep Initiation And Maintenance Disorders 6 43.72 Quite Low
Dizziness 3 43.08 Quite Low
Stroke 3 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Married women whose husbands lived abroad expressed loneliness and thought that this could cause chinta rog.


Positive_regulation (cause) of rog
1) Confidence 0.61 Published 2010 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2975851 Disease Relevance 0.27 Pain Relevance 0.10
Indeed, under basal conditions, 15-min treatment with spiradoline activated Rog, Rog-A, Rog-?
Positive_regulation (activated) of Rog
2) Confidence 0.45 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.26
Indeed, under basal conditions, 15-min treatment with spiradoline activated Rog, Rog-A, Rog-?
Positive_regulation (activated) of Rog
3) Confidence 0.45 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.23
Having too many daughters was considered to be a major cause of worry and chinta rog.
Positive_regulation (cause) of rog
4) Confidence 0.44 Published 2010 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2975851 Disease Relevance 0.17 Pain Relevance 0.04
Popular perception did not implicate education but some thought that lack of it could cause more chinta rog (worry illness).
Positive_regulation (cause) of rog
5) Confidence 0.41 Published 2010 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2975851 Disease Relevance 0.85 Pain Relevance 0.33
Rog-A is resistant to agonist-induced internalization
Positive_regulation (induced) of Rog associated with agonist
6) Confidence 0.33 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.26
There was also no difference in cAMP inhibition after spiradoline activation of Rog and Rog-?
Positive_regulation (activation) of Rog
7) Confidence 0.33 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.07
There was also no difference in cAMP inhibition after spiradoline activation of Rog and Rog-?
Positive_regulation (activation) of Rog
8) Confidence 0.33 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.07
To visualize these RASSLs in living cells, we fused the green fluorescent protein (GFP) to the N-terminus (outer portion) of the RASSL resulting in Rog (RASSL opioid green).
Positive_regulation (resulting) of Rog associated with opioid
9) Confidence 0.33 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0.08 Pain Relevance 0.36
Longer spiradoline pretreatment induces normal AC superactivation at Rog-A, but does not affect the AC response in Rog-?
Positive_regulation (induces) of Rog
10) Confidence 0.33 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.29
Activation of Rog-A inhibits cAMP as fully as Rog (Table 1), indicating that the reduced internalization does not alter acute signaling.


Positive_regulation (Activation) of Rog
11) Confidence 0.30 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.16
Indeed, under basal conditions, 15-min treatment with spiradoline activated Rog, Rog-A, Rog-?
Positive_regulation (activated) of Rog
12) Confidence 0.30 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.26
This indicates that Rog-?
Positive_regulation (indicates) of Rog
13) Confidence 0.28 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.03
Although most of the C-terminal sequence of Rog-?
Positive_regulation (sequence) of Rog
14) Confidence 0.28 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.23
Activation of Rog-A inhibits cAMP as fully as Rog (Table 1), indicating that the reduced internalization does not alter acute signaling.


Positive_regulation (Activation) of Rog
15) Confidence 0.26 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.16

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