INT181249

Context Info Confidence 0.32 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 9 Disease Relevance 2.12 Pain Relevance 3.66

nucleoplasm (TCEA1) nucleolus (TCEA1) nucleus (TCEA1) DNA binding (TCEA1)

Anatomy Link Frequency insula 2 sulcus 1 skin 1 posterior 1 ERD 1 TCEA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Somatosensory cortex 135 100.00 primary somatosensory cortex 134 100.00 amygdala 27 100.00 Thalamus 15 100.00 Hippocampus 12 100.00 insula 53 97.92 Pain 135 97.68 imagery 41 97.36 Central grey 16 96.92 magnetoencephalography 48 94.68

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 190 98.92 Cognitive Disorder 12 98.92 Pain 156 97.68 Urological Neuroanatomy 26 96.92 Neuropathic Pain 70 84.72 Nociception 5 77.68 Adhesions 39 63.68 Peripheral Arterial Disease 39 59.52 INFLAMMATION 47 50.00 Autism 2 43.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While the above described reports provide possible perceptual correlates for bilateral interactions that might occur in SII, such as those identified in the present study, it will remain uncertain until anterior or posterior SII cortical activity is studied under conditions that permit direct correlations of perceptual performance and cortical activity under precisely controlled conditions of contralateral vs. bilateral skin stimulation.

SII Binding (interactions) of in posterior

1) Confidence 0.32 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0

Simoes et al. [9] showed significant suppression of the MEG SII response in humans, with simultaneous inputs delivered to the same skin sites, and Hoechstetter et al. [10] described "interactions" in SII cortex (a response that was not the summation of the ipsilateral and contralateral response) to simultaneous bilateral stimuli.

SII Binding (interactions) of in skin

2) Confidence 0.32 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0.04

While some investigators have proposed that monkey SII occupies a higher position in the somatosensory information processing hierarchy than does SII in cat [20], others have warned that "these are basically descriptive schemes of connections that do not illuminate what features of somesthesis are selectively projected" and that "they also tend to ignore potential interdependence between SI and SII" [26].

SII Binding (occupies) of associated with primary somatosensory cortex

3) Confidence 0.31 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0.06 Pain Relevance 0.44

Converging evidence from many literatures implicates insula as the most reliable region in brain imaging studies on pain [34], and considers it as a limbic integration cortex for complex and preprocessed sensory information with direct association with the SI, SII, prefrontal areas and amygdala, which are important sources of hippocampus and ACC afferents [35-38].

SII Binding (association) of in insula associated with pain, insula, hippocampus, amygdala and imagery

4) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.34 Pain Relevance 1.05

These regions process information in circuits that can broadly be assumed to engage: the affective (amygdala, hippocampus), sensory (thalamus, primary (SI) and secondary (SII) somatosensory cortices), cognitive (ACC, anterior insula), and inhibitory (PAG, hypothalamus) processing during the experience of pain [8].

SII Binding (engage) of in insula associated with pain, cognitive disorder, insula, thalamus, hippocampus, central grey and amygdala

5) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.55 Pain Relevance 0.96

Group comparisons revealed that overall, SII responding of adults with ADHD showed markedly less source power than that of controls (Figure 5C).

SII Binding (overall) of associated with somatosensory cortex and attention deficit hyperactivity disorder

6) Confidence 0.14 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.39 Pain Relevance 0.39

Accordingly, our aim was to characterize ERD and ERS in the alpha and beta bands in SI and SII in response to randomly and predictably presented electrical stimulation of the median nerve in adults with and without ADHD.

SII Binding (characterize) of in ERD associated with somatosensory cortex, primary somatosensory cortex and attention deficit hyperactivity disorder

7) Confidence 0.14 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.43 Pain Relevance 0.33

The Somatosensory Cortex in this study was defined as the combination of the primary somatosensory cortex (SI), which includes the central sulcus in its lower bordering posterior wall (putative BA 3b) with postcentral gyrus (putative BA 1), as well as the secondary somatosensory cortex (SII) localized in the subcentral section lateroventral to the postcentral gyrus on the operculum Rolandi (putative BA 43) [14].

SII Binding (combination) of in sulcus associated with somatosensory cortex and primary somatosensory cortex

8) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561059 Disease Relevance 0.23 Pain Relevance 0.43

Following a wash to remove any unbound substances and/or antibody enzyme reagent, substrate solution was added to the wells allowing the colorometic reaction in proportion to the amount of sTF, sTM and D-D bound.

sTF Binding (bound) of

9) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.12 Pain Relevance 0

General Comments

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