INT181266

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 22
Disease Relevance 0.54
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GPSM2) nucleolus (GPSM2) nucleus (GPSM2)
cytoplasm (GPSM2)
Anatomy Link Frequency
interneurons 7
neurons 4
anterior 1
LGN 1
lenses 1
GPSM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 13 97.16 Very High Very High Very High
interneuron 78 91.60 High High
agonist 13 90.24 High High
anesthesia 42 89.08 High High
Action potential 381 87.36 High High
Glutamate receptor 13 87.36 High High
Thalamus 18 83.88 Quite High
Central nervous system 59 71.20 Quite High
GABAergic 39 68.64 Quite High
nMDA receptor antagonist 13 61.88 Quite High
Disease Link Frequency Relevance Heat
Cramps 2 99.40 Very High Very High Very High
Ganglion Cysts 21 98.88 Very High Very High Very High
Rupture 8 90.64 High High
Knee Injuries 2 90.08 High High
Injury 29 88.24 High High
Optic Nerve Injuries 70 71.08 Quite High
Ocular Hypertension 142 32.16 Quite Low
Disease 12 19.28 Low Low
Hypersensitivity 25 5.00 Very Low Very Low Very Low
Glaucoma 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, surgeons performing ACL reconstruction use screws, pins, buttons, and cramps for graft fixation because of individual preference, or institutional orders.
Gene_expression (screws) of pins associated with cramps
1) Confidence 0.32 Published 2005 Journal BMC Surg Section Body Doc Link PMC552311 Disease Relevance 0.19 Pain Relevance 0
Resorbable screws versus pins for optimal transplant fixation (SPOT) in anterior cruciate ligament replacement with autologous hamstring grafts: rationale and design of a randomized, controlled, patient and investigator blinded trial [ISRCTN17384369]

Background

Gene_expression (Resorbable) of pins in anterior
2) Confidence 0.32 Published 2005 Journal BMC Surg Section Title Doc Link PMC552311 Disease Relevance 0.18 Pain Relevance 0
Images of processed LGN and V1 sections were captured using standard digital camera settings and 1×, 20×, 40×, and 100× objective lenses attached to an upright, bright-field compound microscope (Nikon, Tokyo Japan).
Gene_expression (sections) of LGN in lenses
3) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0 Pain Relevance 0
The LGN was blocked in the coronal plane, frozen on dry ice and stored at ?
Gene_expression (stored) of LGN
4) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.07 Pain Relevance 0.20
Indeed, a cyclic facilitation of relay-mode firing in LGN TC neurons for ?
Gene_expression (neurons) of LGN in neurons
5) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0
rhythm, LGN relay-mode TC neurons form two distinct coalitions, one of which shows a cyclic suppression of firing that is centered on the negative peak of the ?
Gene_expression (relay) of LGN in neurons
6) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.24
Importantly, extracellular single-unit recordings of LGN interneurons confirmed that this latter type of activity commonly occurs spontaneously during in vitro ?
Gene_expression (interneurons) of LGN in interneurons
7) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.12
Our previous work has suggested that LGN ?
Gene_expression (suggested) of LGN
8) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.11
Interestingly, when some LGN interneurons (n = 12 of 27; 44%) were slightly more depolarized (?
Gene_expression (interneurons) of LGN in interneurons
9) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.27
Sagittal slices of the LGN-PGN were prepared and maintained as described previously (Hughes et al., 2002, 2004; L?
Gene_expression (slices) of LGN
10) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.05
The two types of firing observed for LGN interneurons in vitro are clearly comparable with the output of putative interneurons recorded during naturally occurring ?
Gene_expression (interneurons) of LGN in interneurons
11) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.11
Because of the synchrony between HT bursting TC neurons and presumed interneurons observed in vivo (Figure 3D), and since EPSPs observed in LGN interneurons during Cch application in vitro exhibit such strong rhythmicity and are temporally correlated with the LFO, we hypothesized that interneurons receive a convergent synaptic excitation from HT bursting TC neurons (see also Supplemental Results Section G).
Gene_expression (interneurons) of LGN in interneurons
12) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.09
Finally, although burst firing at depolarized membrane potentials is an intrinsic property of LGN interneurons (Zhu et al., 1999a, 1999b; Pape et al., 1994; Cox et al., 2003; Acuna-Goycolea et al., 2008) (Supplemental Results Section E), the unusual form of individual bursts that are evident in these cells during ?
Gene_expression (interneurons) of LGN in interneurons
13) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.04
We found that unlike LGN interneurons, the firing rate of PGN neurons was significantly reduced during ?
Gene_expression (interneurons) of LGN in interneurons
14) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.09
rhythms, LGN interneurons exhibited an increase in firing rate (during ?
Gene_expression (interneurons) of LGN in interneurons
15) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0
In PGN neurons, on the other hand, they were essentially nonrhythmic (Figure S9) and were correlated with the LFO (recorded in the LGN) in only 3 out of 11 cells (?
Gene_expression (recorded) of LGN in neurons
16) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.03
Consistent with this, intracellular recordings of relay-mode LGN TC neurons, obtained in vitro during ?
Gene_expression (neurons) of LGN in neurons
17) Confidence 0.20 Published 2009 Journal Neuron Section Body Doc Link PMC2791173 Disease Relevance 0 Pain Relevance 0.13
Expression of MHCI molecules in LGN and V1 of the common marmoset
Gene_expression (Expression) of LGN
18) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
To investigate the expression of MHCI genes in the marmoset LGN and primary visual cortex, a full-length clone of the heavy chain (HC) of the classical marmoset MHCI gene Caja-G [accession number U59637 [38]) was used for in situ hybridization experiments.
Spec (investigate) Gene_expression (expression) of LGN in primary visual cortex
19) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
It is possible that MHCI genes are expressed prenatally in the marmoset LGN, as the segregation of LGN layers in primates occurs in utero [39,40].
Gene_expression (expressed) of LGN
20) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

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