INT181280

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.00
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
epithelial cells 3
spinal cord 2
lymphoid tissues 2
immune cells 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 117 100.00 Very High Very High Very High
cytokine 27 100.00 Very High Very High Very High
corticosteroid 4 100.00 Very High Very High Very High
Spinal cord 59 99.84 Very High Very High Very High
substance P 44 99.72 Very High Very High Very High
imagery 12 94.92 High High
antagonist 4 86.80 High High
Osteoarthritis 2 82.12 Quite High
Arthritis 106 81.04 Quite High
Neuropeptide 2 80.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 117 100.00 Very High Very High Very High
Airway Remodeling 8 99.62 Very High Very High Very High
Apoptosis 26 96.64 Very High Very High Very High
Asthma 97 95.52 Very High Very High Very High
Autoimmune Disease 6 90.88 High High
Osteoarthritis 2 82.12 Quite High
Lymphatic System Cancer 8 81.12 Quite High
Rheumatoid Arthritis 104 81.04 Quite High
Cancer 88 78.56 Quite High
Toxicity 4 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substance P has been the target of an in vitro selection earlier, resulting in an RNA aptamer with a dissociation constant of 190 nM (16).
Regulation (target) of Gene_expression (selection) of in vitro associated with substance p
1) Confidence 0.07 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0.25 Pain Relevance 0.44
For example, Decoy oligodeoxynucleotides (ODNs), short double stranded DNAs containing a consensus sequence for the NF-B binding sites, specifically block NF-B binding to the target genes and are effective in the down-regulation of pro-inflammatory cytokine gene expression in vitro [105].
Regulation (regulation) of Gene_expression (expression) of in vitro associated with inflammation and cytokine
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.83 Pain Relevance 0.37
In vivo, cell surface expression of CD30 appears to be tightly regulated and restricted to B and T lymphocytes undergoing activation in lymphoid tissues.
Spec (appears) Regulation (regulated) of Gene_expression (expression) of In vivo in lymphoid tissues
3) Confidence 0.01 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.62 Pain Relevance 0.07
If, as our results in the present study suggest, FBLN-1 is implicated in airway remodeling, then the lack of effect of corticosteroids on levels of FBLN-1 in-vivo highlights the need for treatments that target the structural changes which contribute to airway remodeling in asthma.
Regulation (effect) of Gene_expression (levels) of in-vivo associated with asthma, corticosteroid and airway remodeling
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.68 Pain Relevance 0.13
The latter might suggest the presence of certain epigenetic regulatory mechanisms controlling transgene expression in vivo in spinal cord.
Regulation (controlling) of Gene_expression (expression) of in vivo in spinal cord associated with spinal cord
5) Confidence 0.00 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.13
Our work also complements and extends the methods of Smith-Jones et al.[20] which used 68Ga-labeled trastuzumab fragments and 17-AAG for measuring pharmacodynamic changes in HER2/neu expression in vivo to the full antibody with the novel and more potent purine-based Hsp90 inhibitor, PU-H71.[48] Studies include in vitro and in vivo by Western blot analysis, acute biodistribution studies and immunoPET.
Regulation (changes) of Gene_expression (expression) of in vivo
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.27 Pain Relevance 0
We therefore investigated the effects of gram-negative bacterial inflammation on expression of PRXV in lung, lung epithelial cells, and immune cells in vivo and in vitro.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of in vivo in epithelial cells associated with inflammation
7) Confidence 0.00 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.67 Pain Relevance 0.32
We therefore investigated the effects of gram-negative bacterial inflammation on expression of PRXV in lung, lung epithelial cells, and immune cells in vivo and in vitro.
Spec (investigated) Regulation (effects) of in immune cells Gene_expression (expression) of in vivo in epithelial cells associated with inflammation
8) Confidence 0.00 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.67 Pain Relevance 0.32

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