INT181307

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2005
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 23
Disease Relevance 11.15
Pain Relevance 9.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (NGB)
Anatomy Link Frequency
brain 3
cerebrospinal fluids 1
Spinal cord 1
subthalamic nucleus 1
epithelium 1
NGB (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 92 99.32 Very High Very High Very High
Spinal cord 46 99.28 Very High Very High Very High
ischemia 138 99.24 Very High Very High Very High
cerebral cortex 46 98.92 Very High Very High Very High
Pain 345 98.54 Very High Very High Very High
Lasting pain 92 98.50 Very High Very High Very High
Hippocampus 46 97.92 Very High Very High Very High
medulla 46 97.44 Very High Very High Very High
Somatic pain 23 97.44 Very High Very High Very High
Dorsal horn 23 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 161 99.92 Very High Very High Very High
Cv Unclassified Under Development 92 99.24 Very High Very High Very High
Nociception 23 99.08 Very High Very High Very High
Pain 460 98.54 Very High Very High Very High
Diabetes Mellitus 23 94.20 High High
Carbon Monoxide Poisoning 23 87.92 High High
Cv General 4 Under Development 46 75.52 Quite High
Apoptosis 23 72.48 Quite High
Injury 46 72.32 Quite High
Lumbar Puncture Related Headaches 46 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examination of additional normal and chronic pain subjects is underway to determine the factors that may be responsible for neuroglobin expression.
Gene_expression (expression) of neuroglobin associated with lasting pain
1) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.70 Pain Relevance 0.73
It is tempting to speculate that the source of neuroglobin in our samples was from nuclei involved in pain transmission or regulation such as the thalamus, prefrontal cortex, amygdala, or spinal cord dorsal horn somatic pain synaptic regions (e.g. layers 1 and 2 of Rexed).
Gene_expression (source) of neuroglobin in cortex associated with pain, somatic pain, dorsal horn, thalamus, amygdala and spinal cord
2) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 1.13 Pain Relevance 0.94
The source of neuroglobin in the CSF is likely to be brain regions such as the subthalamic nuclei (60% of total brain neuroglobin mRNA expression), frontal lobe, thalamus, occipital pole, pituitary gland, and medulla oblongata [3,14].
Gene_expression (source) of neuroglobin in brain associated with medulla and thalamus
3) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.44 Pain Relevance 0.65
Spinal cord was a less likely source since its neuroglobin mRNA expression was less than 10% of that from the subthalamic nuclei.
Gene_expression (expression) of neuroglobin mRNA in Spinal cord associated with spinal cord
4) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.38 Pain Relevance 0.42
Neuroglobin mRNA was also present in adrenal cells and the ?
Gene_expression (present) of Neuroglobin mRNA
5) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.36 Pain Relevance 0.24
A role in oxygen supply was supported by the very high expression of neuroglobin mRNA in retinal neurons but not the supporting ocular epithelium and other structures [16].
Gene_expression (expression) of neuroglobin mRNA in epithelium
6) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.41 Pain Relevance 0.08
The fact that neuroglobin was not detected in any of the control females in our study makes it unlikely that the expression was related to gender.
Neg (not) Gene_expression (detected) of neuroglobin
7) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.95 Pain Relevance 0.83
For example, neuroglobin expression was 4 times higher in the cerebral cortex than the hippocampus, corresponding to the time for ischemia to cause half-maximal damage (19.1 and 12.7 min, respectively) in these tissues [20].
Gene_expression (expression) of neuroglobin in cerebral cortex associated with ischemia, hippocampus and cerebral cortex
8) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.67 Pain Relevance 0.23
The source of neuroglobin in the CSF is likely to be brain regions such as the subthalamic nuclei (60% of total brain neuroglobin mRNA expression), frontal lobe, thalamus, occipital pole, pituitary gland, and medulla oblongata [3,14].
Gene_expression (expression) of neuroglobin mRNA in brain associated with medulla and thalamus
9) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.43 Pain Relevance 0.65
Neuroglobin mRNA was expressed in the retina [16] and in peripheral nerves suggesting that the mRNA was axonally transported and translated to distal neurons [17].
Gene_expression (expressed) of Neuroglobin mRNA in peripheral nerves
10) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.34 Pain Relevance 0.35
In an attempt to detect low abundance expression of neuroglobin peptide ions that were not selected by MS-MS (false negative results), all MS data from the appropriate CapLC retention times were reassessed at high resolution.
Gene_expression (expression) of neuroglobin
11) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0 Pain Relevance 0
Females have greater pain sensitivity to pressure and other stimuli (lower pain thresholds) [28], but pain is not thought to induce neural hypoxia or any of the known triggers of neuroglobin expression [21].
Gene_expression (expression) of neuroglobin in neural associated with pain and hypoxia
12) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 1.14 Pain Relevance 0.92
Neuroglobin expression was inversely correlated to the sensitivity of the brain regions to ischemia [3].
Gene_expression (expression) of Neuroglobin in brain associated with ischemia
13) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.65 Pain Relevance 0.21
Expression was often patchy within these regions indicating that only select neurons expressed neuroglobin.
Gene_expression (expressed) of neuroglobin in neurons
14) Confidence 0.76 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.43 Pain Relevance 0.60
It is also possible that the proteomic detection of neuroglobin varies depending upon sample preparation, signal-to-noise ratio for relatively low abundance proteins compared to albumin and immunoglobulins that are present in high abundance, duration of storage, factors related to trypsin digestion, capillary liquid chromatography, mass spectrometry or bioinformatic neuroglobin peptide detection.
Gene_expression (detection) of neuroglobin in capillary
15) Confidence 0.66 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.67 Pain Relevance 0.70
Neuroglobin peptides were detected in 2 of the 3 CapLC runs for subjects #1 and #2, but only in 1 run for subject #3.
Gene_expression (detected) of Neuroglobin
16) Confidence 0.66 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.16 Pain Relevance 0.16
BLAST sequence analysis of all six peptides identified only one protein: hypothetical 16.9 kDa protein (neuroglobin: NREF and iProClass NF00135839; SwissProt/TrEMBL Q9NPG2).


Gene_expression (/) of neuroglobin
17) Confidence 0.66 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0 Pain Relevance 0
These studies of mRNA expression should not be extrapolated into relative levels of protein expression or neuroglobin turnover since concordance between microarray and proteomic studies can be as low at 13% [19].
Gene_expression (expression) of neuroglobin
18) Confidence 0.59 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.34 Pain Relevance 0.18
Neuroglobin protein has not been previously detected in cerebrospinal fluids.


Neg (not) Gene_expression (detected) of Neuroglobin protein in cerebrospinal fluids
19) Confidence 0.59 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.11 Pain Relevance 0.05
Human neuroglobin mRNA is predominantly expressed in brain with high signal in the frontal lobe, subthalamic nucleus and thalamus.
Gene_expression (expressed) of neuroglobin mRNA in thalamus associated with thalamus
20) Confidence 0.59 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.24 Pain Relevance 0.10

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