INT181316

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.65
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ALPL) plasma membrane (ALPL)
ALPL (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 3 99.72 Very High Very High Very High
cINOD 76 98.60 Very High Very High Very High
spondylitis 6 97.56 Very High Very High Very High
Clonidine 48 89.32 High High
Inflammation 85 88.36 High High
spinal inflammation 75 87.12 High High
withdrawal 3 80.12 Quite High
cytokine 1 72.48 Quite High
visual analogue scale 6 58.52 Quite High
imagery 38 51.16 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 49 97.56 Very High Very High Very High
Disorders Of Creatine Metabolism 3 94.04 High High
Ankylosis 2 92.16 High High
INFLAMMATION 123 88.36 High High
Osteophyte 1 78.00 Quite High
Phosphate Metabolism Disorders 165 76.72 Quite High
Hypercalcemia 8 76.64 Quite High
Osteoporosis 4 68.84 Quite High
Muscle Weakness 3 63.04 Quite High
Endometriosis (extended) 3 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a significant increase of alkaline phosphatase activity in the serum was noted.
Positive_regulation (increase) of alkaline
1) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.20 Pain Relevance 0.40
So far, it is not clear whether this means an actual increase in TNSALP function or concentration, or whether it is caused by a variation in sample results measured at different time points.
Spec (whether) Positive_regulation (increase) of TNSALP
2) Confidence 0.57 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.20 Pain Relevance 0.38
However, serum alkaline phosphatase, measured before and after treatment, showed a significant increase from a mean of 39 U/l to 48.5 U/l (p = 0.032, Mann Whitney's exact U-Test) (figure 3).
Positive_regulation (increase) of alkaline
3) Confidence 0.38 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.21 Pain Relevance 0.08
Recent biomarker data generated from ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy) [22,40] showed that previously low levels of osteocalcin and bone alkaline phosphatase were significantly increased under infliximab therapy [41].
Positive_regulation (increased) of bone alkaline phosphatase associated with low back pain, spondylitis and infliximab
4) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 0.86 Pain Relevance 0.58
Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively).
Positive_regulation (increased) of serum bone-specific alkaline phosphatase
5) Confidence 0.08 Published 2005 Journal Nutr J Section Abstract Doc Link PMC554088 Disease Relevance 0.20 Pain Relevance 0
According to our interpretation, the presentation of the cue causes a spatially nonspecific, transient LC–NE response that boosts the processing of any stimuli presented for a brief period thereafter (i.e., the alerting effect).
Positive_regulation (causes) of nonspecific
6) Confidence 0.06 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1915624 Disease Relevance 0 Pain Relevance 0.16

General Comments

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