INT181325

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.64
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TNFAIP1) nucleolus (TNFAIP1) nucleus (TNFAIP1)
embryo development (TNFAIP1) cytoplasm (TNFAIP1)
Anatomy Link Frequency
B12 4
ileum 1
TNFAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 43 77.52 Quite High
monoamine 2 75.36 Quite High
Dopamine 1 73.84 Quite High
Inflammation 9 73.68 Quite High
Serotonin 1 71.52 Quite High
rheumatoid arthritis 1 62.32 Quite High
cytokine 1 60.64 Quite High
cva 3 57.84 Quite High
Paresthesia 8 41.68 Quite Low
peripheral neuropathy 3 12.80 Low Low
Disease Link Frequency Relevance Heat
Disease 18 100.00 Very High Very High Very High
Mycobacterial Infection 40 99.90 Very High Very High Very High
Fatigue 8 98.56 Very High Very High Very High
Macrocytic Anemia 16 97.52 Very High Very High Very High
Thrombosis 12 97.40 Very High Very High Very High
Convulsion 14 97.04 Very High Very High Very High
Movement Disorders 6 95.48 Very High Very High Very High
Frailty 8 92.72 High High
Congenital Anomalies 6 91.76 High High
Fever 24 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These patients switched back due to side effects – one cited neurological and gastrointestinal symptoms (her post-trial serum B12 level was significantly increased from baseline) and the other cited decreased energy (his post-trial serum B12 level was not available).
Positive_regulation (increased) of B12 in B12 associated with fatigue
1) Confidence 0.36 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0.18 Pain Relevance 0
Segmental involvement of the distal ileum, such as in tuberculosis, can cause vitamin B12 deficiency.
Positive_regulation (cause) of B12 in B12 associated with mycobacterial infection
2) Confidence 0.19 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2329654 Disease Relevance 1.54 Pain Relevance 0
We concluded that M. tuberculosis had caused the terminal ileum disease and possibly vitamin B12 deficiency in our patient.
Spec (possibly) Positive_regulation (caused) of B12 in ileum associated with mycobacterial infection and disease
3) Confidence 0.19 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2329654 Disease Relevance 0.82 Pain Relevance 0
Homocysteine can be remethylated to methionine via the 5-methyl-tetrahydrofolate pathway that is mediated by the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme and requires B12 and folic acid, or condensed with serine to form cysthionine in a reaction that uses vitamin B6 [17].
Positive_regulation (requires) of B12 in B12
4) Confidence 0.19 Published 2010 Journal Trials Section Body Doc Link PMC2822769 Disease Relevance 0.45 Pain Relevance 0.33
Homocysteine is generated via the metabolism of methionine and requires vitamins B6, B12 and folate.
Positive_regulation (requires) of B12 in B12
5) Confidence 0.12 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.66 Pain Relevance 0.18

General Comments

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