INT181341

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.47
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
plaques 2
macrophage 1
monocytes 1
mononuclear cells 1
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 302 99.64 Very High Very High Very High
Arthritis 4 97.20 Very High Very High Very High
Inflammation 384 95.44 Very High Very High Very High
Central nervous system 250 92.56 High High
cytokine 78 92.12 High High
antagonist 78 91.52 High High
rheumatoid arthritis 6 89.44 High High
chemokine 433 88.64 High High
Spinal cord 40 82.48 Quite High
agonist 21 61.32 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 392 99.64 Very High Very High Very High
Multiple Sclerosis 395 99.18 Very High Very High Very High
Recurrence 80 99.08 Very High Very High Very High
Arthritis 4 97.20 Very High Very High Very High
Adhesions 49 96.80 Very High Very High Very High
INFLAMMATION 388 95.44 Very High Very High Very High
Injury 9 94.40 High High
Central Nervous System Disease 240 92.56 High High
Apoptosis 27 91.80 High High
Rheumatoid Arthritis 11 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR2 is the main, but not exclusive, functional receptor for CCL2 [4], and as discussed above, the CCL2 – CCR2 interaction appears to play a key role in the development of EAE lesions.
CCR2 Binding (interaction) of associated with multiple sclerosis
1) Confidence 0.32 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.69 Pain Relevance 0.11
Nevertheless, the data from EAE and observations in MS suggest that the CCR2 – CCL2 interaction is important in the development of plaques.
CCR2 Binding (interaction) of in plaques associated with multiple sclerosis
2) Confidence 0.32 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.19
Experimental evidence now suggests that CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8 and CXCR3 on hematogenous mononuclear cells recognize these chemoattractant and regulatory molecules to induce cell differentiation, adhesion or migration of distinct inflammatory cells in peripheral lymphoid organs, at the BBB and in the CNS during the course of EAE.
CCR2 Binding (recognize) of in mononuclear cells associated with multiple sclerosis, inflammation, central nervous system and adhesions
3) Confidence 0.25 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.05 Pain Relevance 0.27
Microglia, macrophages and perivascular mononuclear cells show some degrees of immune reactivity for CCR2 in chronic active plaques in several studies, but the expression of CCR2 is generally low in MS lesions.
CCR2 Binding (reactivity) of in plaques associated with multiple sclerosis
4) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.81 Pain Relevance 0.15
This observation confirmed the role of CCL2 – CCR2 interaction in the development of relapses.
CCR2 Binding (interaction) of associated with recurrence
5) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.46 Pain Relevance 0.07
It binds to CCR2, a receptor that is highly expressed on circulating blood DCs and monocytes, and thus primarily controls their recruitment from the blood vessels to the tissue.
CCR2 Binding (binds) of in monocytes
6) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.75 Pain Relevance 0.44
Binding of CCL2 to its CCR2 receptor can also be blocked by RS-504393, which is able to inhibit macrophage infiltration and activation (Kitagawa et al 2004).
CCR2 Binding (receptor) of in macrophage
7) Confidence 0.12 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.74 Pain Relevance 0.40
2AAR-YFP/CFP to become internalized following stimulation, whereas upon activation with CCL2 CCR2 was readily detected on endosomal structures (Figure 4B).
CCR2 Binding (activation) of
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0 Pain Relevance 0.13

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