INT181345

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 9.68
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl12) extracellular region (Ccl12)
Anatomy Link Frequency
immune cell 1
Ccl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 192 100.00 Very High Very High Very High
Inflammation 196 98.16 Very High Very High Very High
cytokine 53 96.00 Very High Very High Very High
Inflammatory response 13 92.32 High High
Central nervous system 122 92.24 High High
Spinal cord 16 80.64 Quite High
Multiple sclerosis 120 5.00 Very Low Very Low Very Low
Demyelination 24 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Neuritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 4 100.00 Very High Very High Very High
Aging 64 99.24 Very High Very High Very High
Infection 326 99.12 Very High Very High Very High
INFLAMMATION 209 98.16 Very High Very High Very High
Mycobacterial Infection 290 96.60 Very High Very High Very High
Multiple Sclerosis 158 96.60 Very High Very High Very High
Togavirus Infection 150 96.12 Very High Very High Very High
Central Nervous System Disease 96 92.24 High High
Alzheimer's Dementia 16 91.72 High High
Stress 11 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Ccl12 in immune cell associated with chemokine, injury and infection
1) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.51 Pain Relevance 0.26
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Ccl12 associated with chemokine
2) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.88 Pain Relevance 0.62
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
Positive_regulation (upregulation) of CCL12 associated with multiple sclerosis
3) Confidence 0.47 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.45 Pain Relevance 0.25
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
Positive_regulation (upregulation) of MCP-5 associated with multiple sclerosis
4) Confidence 0.47 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.45 Pain Relevance 0.25
While the chemokines Ccl8, Ccl12, Ccl5 and Ccl7 found to be elevated in the context of aging may directly promote inflammation, the specific influence of each of these cytokines in the prostate remains to be established.
Positive_regulation (elevated) of Ccl12 associated with chemokine, aging, inflammation and cytokine
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.92 Pain Relevance 0.32
In addition to early induction of CXC chemokines, we also show that induction of genes encoding C-C chemokines namely CCL-2 (MCP-1), CCL8 (MCP-2), CCL12 (MCP-5) and CCL22 (MDC) occurs on D12 and progressively increases between D15 and D21 post infection (Table 7).
Positive_regulation (induction) of CCL12 associated with chemokine and infection
6) Confidence 0.26 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.24 Pain Relevance 0.19
In addition to early induction of CXC chemokines, we also show that induction of genes encoding C-C chemokines namely CCL-2 (MCP-1), CCL8 (MCP-2), CCL12 (MCP-5) and CCL22 (MDC) occurs on D12 and progressively increases between D15 and D21 post infection (Table 7).
Positive_regulation (induction) of MCP-5 associated with chemokine and infection
7) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.24 Pain Relevance 0.19

General Comments

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