INT181347

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 9.08
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl13) extracellular space (Cxcl13) extracellular region (Cxcl13)
cell-cell signaling (Cxcl13)
Anatomy Link Frequency
B-cell 2
follicles 1
gut associated lymphoid tissue 1
immune system 1
lung 1
Cxcl13 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 115 99.88 Very High Very High Very High
rheumatoid arthritis 228 98.48 Very High Very High Very High
Chronic pancreatitis 222 97.48 Very High Very High Very High
Inflammation 220 97.04 Very High Very High Very High
cytokine 13 95.12 Very High Very High Very High
fibrosis 54 83.52 Quite High
Inflammatory response 15 82.56 Quite High
Central nervous system 61 78.04 Quite High
Demyelination 12 40.28 Quite Low
Kinase C 1 25.44 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 51 99.52 Very High Very High Very High
Primary Sclerosing Cholangitis 180 99.16 Very High Very High Very High
Rheumatoid Arthritis 230 98.48 Very High Very High Very High
Epstein-barr Virus 8 98.00 Very High Very High Very High
Pancreatitis 324 97.48 Very High Very High Very High
Syndrome 36 97.20 Very High Very High Very High
INFLAMMATION 223 97.04 Very High Very High Very High
Togavirus Infection 75 97.04 Very High Very High Very High
Hematological Disease 1 96.68 Very High Very High Very High
Graves' Ophthalmopathy 6 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL13 and its receptor CXCR5 are involved in the organization and compartmentalization of lymph follicles and are overexpressed in various autoimmune diseases, like rheumatoid arthritis, Sjögren's syndrome, Hashimoto's thyreoiditis and Graves' disease, and in gut associated lymphoid tissue (GALT) of patients affected by ulcerative colitis.[20]–[23] This novel finding provides a further functional link between AIPC and some of the most frequently reported AIPC-associated conditions, such as Sjögren's syndrome and ulcerative colitis and gives further support to the still debated hypothesis of an autoimmune pathogenesis of AIPC.
Gene_expression (overexpressed) of CXCL13 in gut associated lymphoid tissue associated with inflammatory bowel disease, autoimmune disease, syndrome, graves' ophthalmopathy, rheumatoid arthritis and disease
1) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.48 Pain Relevance 0.18
Moreover, the expression of CXCL13 (BCA-1, B-cell attracting chemokine 1) and CXCR5 (BLR1, Burkitt lymphoma receptor-1) was examined, aiming at identifying further AIPC-specific tissue markers possibly related to the autoimmune pathogenesis of this disorder.
Spec (examined) Gene_expression (expression) of CXCL13 in B-cell associated with chemokine and epstein-barr virus
2) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.71 Pain Relevance 0.26
Moreover, the expression of CXCL13 (BCA-1, B-cell attracting chemokine 1) and CXCR5 (BLR1, Burkitt lymphoma receptor-1) was examined, aiming at identifying further AIPC-specific tissue markers possibly related to the autoimmune pathogenesis of this disorder.
Spec (examined) Gene_expression (expression) of BCA-1 in B-cell associated with chemokine and epstein-barr virus
3) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.71 Pain Relevance 0.26
CXCL13 and CXCR5 are in fact involved in normal lymphocyte trafficking and homing in secondary lymphoid organs and are highly expressed in various autoimmune diseases characterized by the occurrence of ectopic lymphoid follicles [20]–[23], which are also a prominent feature of AIPC.
Gene_expression (expressed) of CXCL13 in follicles associated with autoimmune disease
4) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.87 Pain Relevance 0.35
Median CXCL13-mRNA levels in AIPC were also significantly higher than in the other groups, with a 21-fold increase compared to CP (p?
Gene_expression (higher) of CXCL13 associated with chronic pancreatitis
5) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.13 Pain Relevance 0.49
To confirm the overexpression of CXCR5 and CXCL13 in AIPC, real-time quantitative PCR was additionally performed.
Gene_expression (overexpression) of CXCL13
6) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.03 Pain Relevance 0.46
Homeostatic chemokines were detected with goat anti mouse CXCL13 and goat anti mouse CCL21.
Gene_expression (detected) of CXCL13 associated with chemokine
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0 Pain Relevance 0.09
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Gene_expression (genes) of Cxcl13 associated with chemokine
8) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.84 Pain Relevance 0.60
Analysis of CXCL13 production in lung lysates and serum did not reveal any noteworthy differences between naïve and vaccinated mice (data not shown).
Gene_expression (production) of CXCL13 in lung
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.20 Pain Relevance 0.07
CCL21, CCL25, CXCL13) are constitutively expressed and control physiologic trafficking of cells of the adoptive immune system during hematopoiesis and immunosurveillance.
Gene_expression (expressed) of CXCL13 in immune system associated with hematological disease
10) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.52 Pain Relevance 0.68
As synovial tissues containing sites of ectopic lymphoneogenesis have been demonstrated to be closely associated with increased expression levels of CXCL13 and LT?
Gene_expression (levels) of CXCL13
11) Confidence 0.30 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.15
As synovial tissues containing sites of ectopic lymphoneogenesis have been demonstrated to be closely associated with increased expression levels of CXCL13 and LT?
Gene_expression (expression) of CXCL13
12) Confidence 0.30 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.15

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